In vitro antiviral and antioxidant activities of silymarin and panax ginseng on vero cells infected with bovine ephemeral fever virus and bluetongue virus

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dc.contributor.authorDik, Burak.
dc.contributor.authorAvci, Oguzhan.
dc.contributor.authorDik, Irmak.
dc.date.accessioned2020-03-26T20:14:40Z
dc.date.available2020-03-26T20:14:40Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Veteriner Fakültesi, Klinik Öncesi Bilimler Bölümüen_US
dc.description.abstractThe inadequacy of antiviral drugs in the treatment of viral diseases, has led to herbal medicine. It was aimed to determine the antiviral and antioxidant activities of Silymarin and Panax ginseng against Bovine ephemeral fever virus (BEFV) and Bluetongue virus (BTV) in permanent cell culture. Silymarin and Panax ginseng were dissolved at the concentration of 400 mu g/mL within distilled water. The cell proliferation test was used to evaluate the cytotoxic activity of the Silymarin and Panax ginseng. They were cytotoxic over 50 mu g/mL dose in Vero cells. Hence, antiviral activities of subjects were investigated against BEFV at the 25 and 50 mu g/mL doses. However, they did not show antiviral activity at any dose level against BTV. Effects of Silymarin and Panax ginseng were evaluated on the total antioxidant capacity (TAC) and thiobarbituric acid reactive substances (TBARS), oxidative stress marker, levels in Vero cells infected with BEFV and BTV. Silymarin (25 and 50 mu g/mL) affected TAC levels in Vero cells infected with BEFV, but it did not effect the TBARS levels in Vero cells infected with BEFV and BTV. Panax ginseng decreased TBARS levels in both diseases, although it did not change TAC levels at same doses on Vero cells infected with BEFV and BTV. In conclusion, it is referred that Silymarin and Panax ginseng may have antiviral some viruses and they may have antioxidant, cell protective and inhibitory effects of virus replication.en_US
dc.identifier.citationDik, B., Avci, O., Dik, I. (2019). In Vitro Antiviral and Antioxidant Activities of Silymarin and Panax Ginseng on Vero Cells Infected with Bovine Ephemeral Fever Virus and Blue Tongue Virus. Acta Poloniae Pharmaceutica-Drug Research, 76(2), 291-297.
dc.identifier.doi10.32383/appdr/96330en_US
dc.identifier.endpage297en_US
dc.identifier.issn0001-6837en_US
dc.identifier.issn2353-5288en_US
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage291en_US
dc.identifier.urihttps://dx.doi.org/10.32383/appdr/96330
dc.identifier.urihttps://hdl.handle.net/20.500.12395/37916
dc.identifier.volume76en_US
dc.identifier.wosWOS:000468126500010en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorDik, Burak.
dc.institutionauthorAvci, Oguzhan.
dc.institutionauthorDik, Irmak.
dc.language.isoenen_US
dc.publisherPOLSKIE TOWARZYSTWO FARMACEUTYCZNEen_US
dc.relation.ispartofACTA POLONIAE PHARMACEUTICAen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAntiviralen_US
dc.subjectBluetongue virusen_US
dc.subjectBovine ephemeral fever virusen_US
dc.subjectPanax ginsengen_US
dc.subjectSilymarinen_US
dc.titleIn vitro antiviral and antioxidant activities of silymarin and panax ginseng on vero cells infected with bovine ephemeral fever virus and bluetongue virusen_US
dc.typeArticleen_US

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