Association between trp64arg polymorphism of the ?3 adrenoreceptor gene and female sex in obese Turkish children and adolescents

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dc.authorid0000-0001-7672-8100
dc.authorid0000-0003-4266-393X
dc.authorid0000-0001-5350-2192
dc.authorid0000-0002-6993-8780
dc.authorid0000-0003-0880-7215
dc.authorid0000-0002-6190-878X
dc.contributor.authorYılmaz, Resul
dc.contributor.authorAteş, Ömer
dc.contributor.authorGül, Ali
dc.contributor.authorKasap, Tuba
dc.contributor.authorÖzer, Samet
dc.contributor.authorEnsari, Emel
dc.date.accessioned2020-03-26T20:12:39Z
dc.date.available2020-03-26T20:12:39Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractPurpose: The beta 3-adrenergic receptor (ADRB3) is expressed in visceral adipose tissue and has been speculated to contribute to lipolysis, energy metabolism, and regulation of the metabolic rate. In this study, we aimed to investigate the association of polymorphism of the ADRB3 gene with the sex of children with obesity and related pathologies. Methods: ADRB3 gene trp64arg genotyping was conducted in 441 children aged 6-18 years. Among these subjects, 264 were obese (103 boys; 161 girls) and 179 were of normal weight (81 boys; 98 girls). In the obese group, fasting lipids, glucose and insulin levels, and blood pressure were measured. Metabolic syndrome (MS) was defined according to the modified World Health Organization criteria adapted for children. Results: The frequency of trp64arg genotype was similar in obese and normal weight children. In obese children, serum lipid, glucose, and insulin levels; homeostasis model assessment of insulin resistance (HOMA-IR) scores; and MS were not different between arg allele carriers (trp64arg) and noncarriers (trp64trp). In 264 obese children, genetic analysis results revealed that the arg allele carriers were significantly higher in girls than in boys (p=0.001). In the normal weight group, no statistically significant difference was found between genotypes of boys and girls (p=0.771). Conclusion: Trp64arg polymorphism of the ADRB3 gene was not associated with obesity and MS in Turkish children and adolescents. Although no relationships were observed between the genotypes and lipids, glucose/insulin levels, or HOMA-IR, the presence of trp64arg variant was frequent in obese girls, which can lead to weight gain as well as difficulty in losing weight in women.en_US
dc.identifier.citationYılmaz, R., Ateş, Ö., Gül, A., Kasap, T., Özer, S., Ensari, E. (2019). Association Between Trp64arg Polymorphism of the β3 adrenoreceptor Gene and Female Sex in Obese Turkish Children and Adolescents. Pediatric Gastroenterology, Hepatology & Nutrition, 22(5), 460-469.
dc.identifier.doi10.5223/pghn.2019.22.5.460en_US
dc.identifier.endpage469en_US
dc.identifier.issn2234-8646en_US
dc.identifier.issn2234-8840en_US
dc.identifier.issue5en_US
dc.identifier.pmid31555571en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage460en_US
dc.identifier.urihttps://dx.doi.org/10.5223/pghn.2019.22.5.460
dc.identifier.urihttps://hdl.handle.net/20.500.12395/37512
dc.identifier.volume22en_US
dc.identifier.wosWOS:000485766800006en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorYılmaz, Resul
dc.language.isoenen_US
dc.publisherKOREAN SOC PEDIATRIC GASTROENTEROLOGY & NUTRITIONen_US
dc.relation.ispartofPEDIATRIC GASTROENTEROLOGY HEPATOLOGY & NUTRITIONen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectObesityen_US
dc.subjectChilden_US
dc.subjectbeta 3-adrenergic receptoren_US
dc.subjectGene polymorphismen_US
dc.titleAssociation between trp64arg polymorphism of the ?3 adrenoreceptor gene and female sex in obese Turkish children and adolescentsen_US
dc.typeArticleen_US

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