Effects of Caffeic Acid Phenethyl Ester (CAPE) on Hepatopulmonary Syndrome

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dc.contributor.authorTekin, Ahmet
dc.contributor.authorTurkyilmaz, Serdar
dc.contributor.authorKucukkartallar, Tevfik
dc.contributor.authorCakir, Murat
dc.contributor.authorYilmaz, Huseyin
dc.contributor.authorEsen, Hasan
dc.contributor.authorAtes, Burhan
dc.date.accessioned2020-03-26T18:14:20Z
dc.date.available2020-03-26T18:14:20Z
dc.date.issued2011
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe aim of this study was to investigate the effects of caffeic acid phenethyl ester (CAPE) on inflammatory and related histopathological changes in the lung and liver in experimental hepatopulmonary syndrome (HPS) model. Forty Sprague Dawley rats were used in this study. The animals were divided into four groups of ten rats each. Group 1 and 2 was subjected the common bile duct (CBD) but not ligated, Group 3; (cirrhosis + saline): the CBD was ligated and was given intraperitoneal saline infusion treatment during 5 weeks. Group 4; (cirrhosis + CAPE): the CBD was ligated and was given intraperitoneal CAPE infusion treatment during 5 weeks. A 5-week waiting period was observed for the development of cirrhosis and the rats' lungs and liver were taken for histopathological examination. The induction of HPS resulted in a significant increase in serum bilurubin, AST, ALT, and NO levels, and decrease PO2 and O-2 saturation. The use of CAPE significant decrease these parameters. Histopathological examination revealed less congestion, portal inflammation, and nodular formations of the liver, and less congestion, emphysematous and inflammatory changes and smallest perialviolar vascular diameters, in the lung in the cirrhosis + CAPE groups than in the other groups. CAPE treatment may be a potential approach for the treatment of hepatopulmonary syndrome in the future.en_US
dc.identifier.doi10.1007/s10753-010-9270-8en_US
dc.identifier.endpage619en_US
dc.identifier.issn0360-3997en_US
dc.identifier.issn1573-2576en_US
dc.identifier.issue6en_US
dc.identifier.pmid21046212en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage614en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s10753-010-9270-8
dc.identifier.urihttps://hdl.handle.net/20.500.12395/26392
dc.identifier.volume34en_US
dc.identifier.wosWOS:000297198400013en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSPRINGER/PLENUM PUBLISHERSen_US
dc.relation.ispartofINFLAMMATIONen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectcirrhosisen_US
dc.subjecthepatopulmonary syndromeen_US
dc.subjectratsen_US
dc.subjectCAPEen_US
dc.titleEffects of Caffeic Acid Phenethyl Ester (CAPE) on Hepatopulmonary Syndromeen_US
dc.typeArticleen_US

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