Does lens status affect the course of early intraocular pressure and anterior chamber changes after intravitreal injection?

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dc.contributor.authorKerimoglu, Hurkan
dc.contributor.authorOzturk, Banu T.
dc.contributor.authorBozkurt, Banu
dc.contributor.authorOkka, Mehmet
dc.contributor.authorOkudan, Suleyman
dc.date.accessioned2020-03-26T18:14:11Z
dc.date.available2020-03-26T18:14:11Z
dc.date.issued2011
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractPurpose: This study aimed to observe changes in anterior chamber parameters and the course of intraocular pressure (IOP) after injection of 0.1 ml intravitreal triamcinolone acetonide (TA) and to determine differences between phakic and pseudophakic eyes without vitreous reflux. Methods: A prospective observational clinical trial was conducted with 89 patients who received an intravitreal injection of TA and did not display vitreous reflux. Intraocular pressure measurements were made before injection and at 3, 10, 20, 30 and 40 mins after injection. Pentacam measurements were made before injection and at 5, 15, 30 and 45 mins after injection. Results: Anterior chamber depth (ACD) and anterior chamber volume (ACV) were significantly greater in pseudophakic eyes than in phakic eyes at all measurement time-points (p < 0.001). There was a decrease in both ACD and ACV at 5 mins after injection, and a gradual increase to normal values was observed at 15, 30 and 45 mins after injection in all study eyes. Compared with pre-injection measurements, changes in ACD and ACV were statistically significant at each time-point in both phakic and pseudophakic eyes (p < 0.001). A significant increase in IOP within 3 mins of injection was observed in both groups and a more rapid decrease 10 mins after injection was observed in pseudophakic eyes. The differences in IOP between phakic and pseudophakic eyes at all measurement time-points, except baseline and 3 mins after injection, were statistically significant (p < 0.001). Intraocular pressure < 30 mmHg and < 24 mmHg was recorded in all pseudophakic eyes at 10 and 20 mins after intravitreal injection, respectively. Conclusions: Following intravitreal injection of 0.1 ml TA, without vitreous reflux, IOP decreased to safe levels more quickly in pseudophakic eyes than in phakic eyes. Although there were more pronounced changes in anterior chamber parameters in pseudophakic eyes, these changes were reversible without any residual clinical significance.en_US
dc.identifier.doi10.1111/j.1755-3768.2009.01656.xen_US
dc.identifier.endpage142en_US
dc.identifier.issn1755-375Xen_US
dc.identifier.issue2en_US
dc.identifier.pmid19799586en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage138en_US
dc.identifier.urihttps://dx.doi.org/10.1111/j.1755-3768.2009.01656.x
dc.identifier.urihttps://hdl.handle.net/20.500.12395/26342
dc.identifier.volume89en_US
dc.identifier.wosWOS:000287664700033en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWILEY-BLACKWELLen_US
dc.relation.ispartofACTA OPHTHALMOLOGICAen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectanterior chamber depthen_US
dc.subjectintraocular pressureen_US
dc.subjectintravitreal injectionen_US
dc.subjectlens statusen_US
dc.titleDoes lens status affect the course of early intraocular pressure and anterior chamber changes after intravitreal injection?en_US
dc.typeArticleen_US

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