Effects of propofol and sevoflurane on isolated human umbilical arteries pre-contracted with dopamine, adrenaline and noradrenaline

Basit Öğe Kaydı
dc.contributor.authorGunduz, Ergun
dc.contributor.authorArun, Oguzhan
dc.contributor.authorBagci, Sengal Taylan
dc.contributor.authorOc, Bahar
dc.contributor.authorSalman, Alper
dc.contributor.authorYilmaz, Setenay Arzu
dc.contributor.authorCelik, Cetin
dc.date.accessioned2020-03-26T19:05:53Z
dc.date.available2020-03-26T19:05:53Z
dc.date.issued2015
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractAimTo assess the effects of propofol and sevoflurane on the contraction elicited by dopamine, adrenaline and noradrenaline on isolated human umbilical arteries. MethodsUmbilical arteries were cut into endothelium-denuded spiral strips and suspended in organ baths containing Krebs-Henseleit solution bubbled with O-2+CO2 mixture. Control contraction to phenylephrine (10(-5)M) was recorded. Response curves were obtained to 10(-5)M dopamine, 10(-5)M adrenaline or 10(-5)M noradrenaline. Afterwards, either cumulative propofol (10(-6)M, 10(-5)M and 10(-4)M) or cumulative sevoflurane (1.2%, 2.4% and 3.6%) was added to the organ bath, and the responses were recorded. Responses are expressed percentage of phenylephrine-induced contraction (meanstandard deviation) (P<0.05=significance). ResultsPropofol and sevoflurane elicited concentration-dependent relaxations in strips pre-contracted with dopamine, adrenaline and noradrenaline (P<0.05). Highest (10(-4)M) concentration of propofol caused significantly higher relaxation compared with the highest (3.6%) concentration of sevoflurane in the contraction elicited by dopamine. High (10(-5)M) and highest concentrations of propofol caused significantly higher relaxation compared with the high (2.4%) and highest concentrations of sevoflurane on the contraction elicited by adrenaline. High and highest concentrations of sevoflurane caused significantly higher relaxation compared with the high and highest concentrations of propofol on the contraction elicited by noradrenaline. ConclusionDopamine, adrenaline and noradrenaline elicit contractions in human umbilical arteries, and noradrenaline causes the highest contraction. Both propofol and sevoflurane inhibit these contractions in a dose-dependent manner. Propofol caused greater relaxation in the contractions elicited by dopamine and adrenaline while sevoflurane caused greater relaxation in the contraction elicited by noradrenaline.en_US
dc.identifier.doi10.1111/jog.12624en_US
dc.identifier.endpage703en_US
dc.identifier.issn1341-8076en_US
dc.identifier.issn1447-0756en_US
dc.identifier.issue5en_US
dc.identifier.pmid25511326en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage697en_US
dc.identifier.urihttps://dx.doi.org/10.1111/jog.12624
dc.identifier.urihttps://hdl.handle.net/20.500.12395/32084
dc.identifier.volume41en_US
dc.identifier.wosWOS:000353989100006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWILEY-BLACKWELLen_US
dc.relation.ispartofJOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCHen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectadrenalineen_US
dc.subjectdopamineen_US
dc.subjectnoradrenalineen_US
dc.subjectpropofolen_US
dc.subjectsevofluraneen_US
dc.subjectumbilical arteryen_US
dc.titleEffects of propofol and sevoflurane on isolated human umbilical arteries pre-contracted with dopamine, adrenaline and noradrenalineen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu