Alpha Lipoic Acid Treatment Improved Endothelium-dependent Relaxation in Diabetic Rat Aorta

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dc.contributor.authorOkudan, Nilsel
dc.contributor.authorAtalık, Kısmet Esra Nurullahoğlu
dc.contributor.authorGökbel, Hakkı
dc.contributor.authorCanbilen, A.
dc.contributor.authorKara, I.
dc.date.accessioned2020-03-26T18:13:43Z
dc.date.available2020-03-26T18:13:43Z
dc.date.issued2011
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe aim of this study was to ascertain the effects of alpha-lipoic acid (ALA) treatment on relaxant responses of acetylcholine (ACh) and isoprenaline (ISO) in aortic rings precontracted with serotonin (5-HT, 10(-6) M) obtained from streptozotocin (STZ) -induced diabetic rats. Diabetes was induced in the rats by 50 mg/kg streptozotocin (STZ) via an intraperitoneal injection. Rat body and aorta weights were measured. The isometric tension to ACh (10(-9)-3 X 10(-6) M) and ISO (10(-9)-10(-4) M) of 5-HT-precontracted diabetic and non-diabetic rat (control), diabetic-ALA-treated, and ALA-treated aortas, in organ baths were recorded. Six weeks after STZ treatment blood glucose was elevated compared to control rats. In aortic rings from diabetic rats ACh and ISO-induced relaxations were impaired whereas endotheliumin-dependent relaxation to sodium nitroprusside (SNP) was unaffected. ALA (100 mg/kg/day) treatment for 5 weeks enhanced ACh and ISO-induced relaxation in diabetic aortas. This recovering effect was via NO because prevented by incubating the vessels with N-G-nitro-L-arginine methyl ester (L-NAME, a NOS inhibitor). It may be assumed that ALA treatment in vivo, can protect against impaired vascular responsiveness in STZ-induced diabetic rats.en_US
dc.description.sponsorshipScientific Research Foundation of Selcuk UniversitySelcuk Universityen_US
dc.description.sponsorshipThis study is supported by the Scientific Research Foundation of Selcuk University.en_US
dc.identifier.doi10.1248/yakushi.131.739en_US
dc.identifier.endpage744en_US
dc.identifier.issn0031-6903en_US
dc.identifier.issn1347-5231en_US
dc.identifier.issue5en_US
dc.identifier.pmid21532270en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage739en_US
dc.identifier.urihttps://dx.doi.org/10.1248/yakushi.131.739
dc.identifier.urihttps://hdl.handle.net/20.500.12395/26096
dc.identifier.volume131en_US
dc.identifier.wosWOS:000290188300009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPHARMACEUTICAL SOC JAPANen_US
dc.relation.ispartofYAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPANen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectvascular smooth muscleen_US
dc.subjectstreptozotocin-induced diabetesen_US
dc.subjectalpha lipoic aciden_US
dc.subjectvasodilatationen_US
dc.titleAlpha Lipoic Acid Treatment Improved Endothelium-dependent Relaxation in Diabetic Rat Aortaen_US
dc.typeArticleen_US

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