Astımlı çocuklarda serum periostin ve soluk havasında nitrik oksit düzeyi
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Tarih
2018
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Dergi ISSN
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Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Amaç: Periostin, havayolu epitelinden ve akciğer fibroblastlarından, IL-4 ve IL-13 aracılığı ile salgılanan ekstrasellüler matriks proteinidir. Eozinofilik havayolu inflamasyonun göstergesi olduğu kabul edilmektedir. Çalışmada, astımlı çocuk hastalarda serum periostin düzeyinin değerlendirilmesi ve soluk havasında nitrik oksit (FeNO) düzeyleri ile korelasyonunun belirlenmesi amaçlanmıştır. Gereç ve Yöntem: Çalışmaya 7-17 yaş arası, 60 intermittan ve hafif persistan astımlı (29 allerjik, 31 allerjik olmayan) ve 30 sağlıklı kontrol, toplam 90 çocuk (45 kız, 45 erkek) dahil edildi. Hastaların demografik verileri, eozinofil yüzdesi, solunum fonksiyon testi, deri prik testi ve spesifik IgE düzeyleri kaydedildi. FeNO ve serum periostin düzeyi ölçüldü. Bulgular: Çalışmaya alınan tüm bireylerde serum periostin değerlerinin yaşla anlamlı korelasyonu olduğu ve yaşla birlikte azaldığı görüldü (6-12 yaş grubunda 59.0812.79 ng/dl, 13-18 yaş grubunda 46.1811.64 ng/dl, p0.001). Serum periostin düzeyi allerjik astımlı hastalarda 52.1013.93 ng/dl, allerjik olmayanlar da 54.6113.05 ng/dl olup anlamlı fark saptanmadı. FeNO değerleri hasta ve sağlıklı kontrol grubu ile karşılaştırıldığında farklı değildi (15.5 ppb ve 14.0 ppb, p0.486). Hasta grubunda sadece allerjik hastaların FeNO ve periostin değerleri arasındaki korelasyon değerlendirildiğinde istatistiksel olarak anlamlılık saptanmadı (r0.327, p0.077). Ayrıca, serum periostin düzeyi sadece polen duyarlılığı olan grupla karşılaştırıldığında polisensitize olan astımlı çocuklarda daha yüksekti ancak fark istatistiksel olarak anlamlı değildi (58.215.1 ve 44.658.3, p0.065). Sonuç: Bu çalışma ile yeni biyobelirteç olan serum periostin düzeyi çocukluk çağındaki astımlı hastalarda değerlendirildi ve yaşla anlamlı korelasyonunun olduğu gösterildi. İntermittan ve hafif persistan astımlı hastalarda serum periostin düzeyinde anlamlı değişiklik saptanmadı. Çocukluk çağında orta ve ağır persistan astımda, serum periostin düzeyinin değerlendirilmesi için ayrıca çalışmalara ihtiyaç vardır.
Objective: Periostin is an extracellular matrix protein secreted by airway epithelium and pulmonary fibroblasts. Periostin was shown to play a role in eosinophilic airway inflammation. This study evaluated the serum periostin levels and exhaled nitric oxide (FeNO) in children with asthma. Materials and Methods: A total of 60 children with intermittent and mild persistent asthma (29 of them were allergic, and 31 of them were nonallergic) and a control group comprising 30 healthy children, ages between 7 and 17 years, were included in the study. Demographic and clinical data of the patients were recorded. The levels of FeNO and serum periostin were measured. Results: The serum periostin level was significantly correlated with age (59.0812.79 ng/dL in 6–12 years and 46.18 11.64 ng/dL in 13–18 years, p0.001). No statistically significant difference was detected between the children with allergic and nonallergic asthma. The FeNO values were not different in the patient and the control groups. When the correlation between NO and periostin values of the only allergic patients was considered, no statistically significant difference was found (r 0.327, p0.077). Also, the serum periostin levels were higher in polysensitized children compared with only pollen sensitivity, but the “p” value was not at the significance level (58.215.1 and 44.658.3, p0.065).Conclusion: In this study, serum periostin level was evaluated as a biomarker in children with asthma and it was correlated with age. No significant difference was detected in the serum periostin level of children with intermittent and mild-persistent asthma. Further studies are needed to evaluate serum periostin levels in children with moderate and severe-persistent asthma.
Objective: Periostin is an extracellular matrix protein secreted by airway epithelium and pulmonary fibroblasts. Periostin was shown to play a role in eosinophilic airway inflammation. This study evaluated the serum periostin levels and exhaled nitric oxide (FeNO) in children with asthma. Materials and Methods: A total of 60 children with intermittent and mild persistent asthma (29 of them were allergic, and 31 of them were nonallergic) and a control group comprising 30 healthy children, ages between 7 and 17 years, were included in the study. Demographic and clinical data of the patients were recorded. The levels of FeNO and serum periostin were measured. Results: The serum periostin level was significantly correlated with age (59.0812.79 ng/dL in 6–12 years and 46.18 11.64 ng/dL in 13–18 years, p0.001). No statistically significant difference was detected between the children with allergic and nonallergic asthma. The FeNO values were not different in the patient and the control groups. When the correlation between NO and periostin values of the only allergic patients was considered, no statistically significant difference was found (r 0.327, p0.077). Also, the serum periostin levels were higher in polysensitized children compared with only pollen sensitivity, but the “p” value was not at the significance level (58.215.1 and 44.658.3, p0.065).Conclusion: In this study, serum periostin level was evaluated as a biomarker in children with asthma and it was correlated with age. No significant difference was detected in the serum periostin level of children with intermittent and mild-persistent asthma. Further studies are needed to evaluate serum periostin levels in children with moderate and severe-persistent asthma.
Açıklama
Anahtar Kelimeler
İmmünoloji, serum periostin, serum periostin, Astım, Asthma
Kaynak
Astım Allerji İmmünoloji
WoS Q Değeri
N/A
Scopus Q Değeri
Cilt
16
Sayı
2
Künye
Dikener, A. H., Özdemir, H., Ceylan, A., Ünlü, A., Artaç, H. (2018). Astımlı Çocuklarda Serum Periostin ve Soluk Havasında Nitrik Oksit Düzeyi. Astım Allerji İmmünoloji, 16(2), 97-103.
