Effects of gender on the severity of sepsis

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dc.contributor.authorErikoglu, M
dc.contributor.authorSahin, M
dc.contributor.authorOzer, S
dc.contributor.authorAvunduk, MC
dc.date.accessioned2020-03-26T16:57:01Z
dc.date.available2020-03-26T16:57:01Z
dc.date.issued2005
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractPurpose. To investigate the differences between male and female rats and the effects of sex hormones on tissue changes in the lung and liver in a sepsis model. Methods. Sixty Sprague-Dawley rats were divided into six groups of ten. Groups 1 and 2 were the control male and female groups, respectively, subjected only to sepsis; groups 3 and 4 were the male and female groups, respectively, subjected to sepsis, then given 0.04 mg/kg estrogen + progesterone (E-P) intramuscularly (i.m.); and groups 5 and 6 were the male and female groups, respectively, subjected to sepsis, then given 0.5 mg/kg testosterone ( T) i.m. The rats were killed and the histopathological changes in the lung and liver were examined, and plasma endotoxin levels were measured. Results. Histopathological examination revealed less congestion, portal inflammation, and focal necrosis of the liver, and less congestion, edema, and emphysematous and inflammatory changes in the lung in the E-P groups than in the other groups. Moreover, signs of systemic endotoxemia in plasma were proportionally less in the female rats and in the E-P groups than in the male rats and the T groups. Conclusion. Female rats subjected to sepsis showed less liver and lung tissue damage and less systemic endotoxemia than male rats, because of the effects of female sex hormones.en_US
dc.identifier.doi10.1007/s00595-004-2958-3en_US
dc.identifier.endpage472en_US
dc.identifier.issn0941-1291en_US
dc.identifier.issue6en_US
dc.identifier.pmid15912294en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage467en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s00595-004-2958-3
dc.identifier.urihttps://hdl.handle.net/20.500.12395/19701
dc.identifier.volume35en_US
dc.identifier.wosWOS:000229509700008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSPRINGERen_US
dc.relation.ispartofSURGERY TODAYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectsepsisen_US
dc.subjectgenderen_US
dc.subjectlungen_US
dc.subjectliveren_US
dc.subjectendotoxemiaen_US
dc.titleEffects of gender on the severity of sepsisen_US
dc.typeArticleen_US

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