Usability of QTc Dispersion for the Prediction of Orthostatic Intolerance Syndromes

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dc.contributor.authorKarataş, Zehra
dc.contributor.authorAlp, Hayrullah
dc.contributor.authorŞap, Fatih
dc.contributor.authorAltın, Hakan
dc.contributor.authorBaysal, Tamer
dc.contributor.authorKaraarslan, Sevim
dc.date.accessioned2020-03-26T18:32:04Z
dc.date.available2020-03-26T18:32:04Z
dc.date.issued2012
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground: Syncope is defined as transient loss of consciousness and muscle tone, usually of short duration. Noncardiac causes of syncope are classified as orthostatic intolerance syndromes (OIS). QT and QTc (corrected QT) dispersions are the measurements of myocardial instability and show predisposition to arrhythmias. In this study; clinical findings, QT and QTc dispersions of the patients who were diagnosed as OIS were evaluated retrospectively. Also, the aim of the study is to clarify the association of clinical characteristics of unexplained syncope with the outcome of the QT and QTc dispersions in children. Methods: We designed a retrospective study including 152 children and adolescents who had repeated unexplained syncope or presyncope between June 2002 and August 2010. Head-up Tilt table test (HUTT) were performed for all patients. Control group consisted of 67 healthy children. The QT and QTc dispersions were measured from the 12 ECG leads. Results: Eighty-four (55.2%) patients had positive and 68 (44.8%) had negative response to HUTT. QT and QTc dispersions were significantly higher in HUTT-positive group than in negative (p < 0.01, p < 0.001 respectively). Also, QTc dispersion was significantly higher in both vasovagal syncope and postural orthostatic tachycardia syndrome groups than in HUTT-negative group (p < 0.001, p < 0.05 respectively). Specifity and sensitivity of QTc dispersion for predicting positive HUTT are 76.5% and 59.5% respectively. The positive predictive value of the test calculated as 75.8%. Conclusions: These results revealed that we can use QTc dispersion measurement as a noninvasive electrocardiographic test to evaluate OIS for predicting positive result before performing HUTT.en_US
dc.identifier.citationKarataş, Z., Alp, H., Şap, F., Altın, H., Baysal, T., Karaarslan, S., (2012). Usability of QTc Dispersion for the Prediction of Orthostatic Intolerance Syndromes. European Journal of Paediatric Neurology, 16(5), 469-474. Doi:10.1016/j.ejpn.2011.12.009
dc.identifier.doi10.1016/j.ejpn.2011.12.009en_US
dc.identifier.endpage474en_US
dc.identifier.issn1090-3798en_US
dc.identifier.issn1532-2130en_US
dc.identifier.issue5en_US
dc.identifier.pmid22226850en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage469en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.ejpn.2011.12.009
dc.identifier.urihttps://hdl.handle.net/20.500.12395/28605
dc.identifier.volume16en_US
dc.identifier.wosWOS:000308384300009en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKarataş, Zehra
dc.institutionauthorAlp, Hayrullah
dc.institutionauthorŞap, Fatih
dc.institutionauthorAltın, Hakan
dc.institutionauthorBaysal, Tamer
dc.institutionauthorKaraarslan, Sevim
dc.language.isoenen_US
dc.publisherELSEVIER SCI LTDen_US
dc.relation.ispartofEuropean Journal of Paediatric Neurologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectSyncopeen_US
dc.subjectOrthostatic Intolerance Syndromeen_US
dc.subjectQTc Dispersionen_US
dc.subjectHead-Up Tilt Table Testen_US
dc.subjectChildrenen_US
dc.titleUsability of QTc Dispersion for the Prediction of Orthostatic Intolerance Syndromesen_US
dc.typeArticleen_US

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