Serum Biochemistry of Lumpy Skin Disease Virus-Infected Cattle

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dc.contributor.authorSevik, Murat
dc.contributor.authorAvci, Oguzhan
dc.contributor.authorDogan, Muge
dc.contributor.authorInce, Omer Baris
dc.date.accessioned2020-03-26T19:26:16Z
dc.date.available2020-03-26T19:26:16Z
dc.date.issued2016
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractLumpy skin disease is an economically important poxvirus disease of cattle. Vaccination is the main method of control but sporadic outbreaks have been reported in Turkey. This study was carried out to determine the changes in serum biochemical values of cattle naturally infected with lumpy skin disease virus (LSDV). For this study, blood samples in EDTA, serum samples, and nodular skin lesions were obtained from clinically infected animals (n = 15) whereas blood samples in EDTA and serum samples were collected from healthy animals (n = 15). A quantitative real-time PCR method was used to detect Capripoxvirus (CaPV) DNA in clinical samples. A real-time PCR high-resolution melt assay was performed to genotype CaPVs. Serum cardiac, hepatic, and renal damage markers and lipid metabolism products were measured by autoanalyzer. LSDV nucleic acid was detected in all samples which were obtained from clinically infected cattle. The results of serum biochemical analysis showed that aspartate aminotransferase, alkaline phosphatase, total protein, and creatinine concentrations were markedly increased in serum from infected animals. However, there were no significant differences in the other biochemical parameters evaluated. The results of the current study suggest that liver and kidney failures occur during LSDV infection. These findings may help in developing effective treatment strategies in LSDV infection.en_US
dc.identifier.doi10.1155/2016/6257984en_US
dc.identifier.issn2314-6133en_US
dc.identifier.issn2314-6141en_US
dc.identifier.pmid27294125en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://dx.doi.org/10.1155/2016/6257984
dc.identifier.urihttps://hdl.handle.net/20.500.12395/33980
dc.identifier.wosWOS:000376320600001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherHINDAWI LTDen_US
dc.relation.ispartofBIOMED RESEARCH INTERNATIONALen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleSerum Biochemistry of Lumpy Skin Disease Virus-Infected Cattleen_US
dc.typeArticleen_US

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