Assessment of Evidence for Positive Association and Seroprevalence of Hepatitis B and C in Diabetic Patients in a Developing Country

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dc.contributor.authorKorkmaz, Huseyin
dc.contributor.authorKesli, Recep
dc.contributor.authorPamuk, Bans Onder
dc.contributor.authorIpekci, Suleyman Hilmi
dc.contributor.authorTerzi, Yuksel
dc.contributor.authorKebapcilar, Levent
dc.date.accessioned2020-03-26T19:00:59Z
dc.date.available2020-03-26T19:00:59Z
dc.date.issued2015
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground and Aim: The data related to the association between hepatitis virus infections and diabetes mellitus (DM) are conflicting. The aim of this study was to investigate the seroprevalence of hepatitis B virus (HBV) and hepatitis C virus (HCV) and to determine the risk factors affecting the prevalence in Turkish patients with type 1 DM and type 2 DM. Methods: The study consisted of 736 diabetic and 505 nondiabetic patients. Serological investigation for the hepatitis B surface antigen (HBsAg) and the HCV antibody (anti-HCV) was performed with a third-generation commercial chemiluminescence assay. The presence of HBsAg was considered as indicator of HBV infection. The HCV infection in the patients with positive anti-HCV was confirmed by a real-time polymerase chain reaction assay. The patients were divided according to their HBV and HCV infection status, and their demographic features, diabetes properties, general risk factors, and aminotransferase levels were analyzed. Results: There was no significant difference in the seropositivity rate for the HBsAg (3.8% vs 3.0%, P > 0.43; odds ratio, 1.292; 95% confidence interval, 0.683-2.444). However, anti-HCV seropositivity was significantly increased in the DM group (3.3% vs 1.8%, P < 0.03; odds ratio, 2.398; 95% confidence interval, 1.025-5.609). Increased aminotransferase levels and a history of blood transfusions were positively correlated with both HBV and HCV infection. Moreover, a history of surgical procedures and high glycated hemoglobin A1c levels were positively associated with HBsAg antigen seropositivity. Conclusions: Although no significant difference in the seropositivity of the HBsAg was determined, a high prevalence of HCV infection was detected in the DM patients compared to healthy controls.en_US
dc.identifier.doi10.1097/JIM.0000000000000126en_US
dc.identifier.endpage257en_US
dc.identifier.issn1081-5589en_US
dc.identifier.issn1708-8267en_US
dc.identifier.issue2en_US
dc.identifier.pmid25415060en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage251en_US
dc.identifier.urihttps://dx.doi.org/10.1097/JIM.0000000000000126
dc.identifier.urihttps://hdl.handle.net/20.500.12395/31869
dc.identifier.volume63en_US
dc.identifier.wosWOS:000348595000010en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBMJ PUBLISHING GROUPen_US
dc.relation.ispartofJOURNAL OF INVESTIGATIVE MEDICINEen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectdiabetes mellitusen_US
dc.subjecthepatitis Ben_US
dc.subjecthepatitis Cen_US
dc.subjectseroprevalenceen_US
dc.titleAssessment of Evidence for Positive Association and Seroprevalence of Hepatitis B and C in Diabetic Patients in a Developing Countryen_US
dc.typeArticleen_US

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