Functional group efects of new calixarene derivatives on catalytic and enantioselective behavior of lipase
Yükleniyor...
Dosyalar
Tarih
2019
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
TAYLOR & FRANCIS LTD
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
In this study, two new calixarene derivatives bearing thiourea and carbamate moieties were synthesized and characterized. Moreover, thiourea- and carbamate-bridged calixarene derivatives with Fe3O4 magnetic nanoparticle were employed for the first time as the convenient additives in the encapsulation process of lipase. The results of catalytic activity and enantioselectivity of the encapsulated lipases in the hydrolysis reaction of racemic flurbiprofen methyl ester indicate that both of the encapsulated lipases (Enc-TuC[4]@Fe3O4 and Enc-CbC[4]@Fe3O4) exhibit higher conversion and enantioselectivity compared to the free-encapsulated lipase (Enc-Lipase). However, the highest affinities result was obtained when the encapsulated lipase (Enc-CbC[4]@Fe3O4) was used in the kinetic resolution reaction of racemic flurbiprofen methyl ester.
Açıklama
Anahtar Kelimeler
Calixarene, enantioselectivity, Fe(3)O(4)nanoparticles, flurbiprofen, lipase
Kaynak
POLYCYCLIC AROMATIC COMPOUNDS
WoS Q Değeri
Q3
Scopus Q Değeri
Q3
Cilt
39
Sayı
4
Künye
Dogan, V., Sayin, S., Uyanik, A., Yilmaz, M. (2019). Functional Group Effects of New Calixarene Derivatives on Catalytic and Enantioselective Behavior of Lipase. Polycyclic Aromatic Compounds, 39(4), 318-331.
