Prevention of postoperative nausea and vomiting after thyroidectomy - Combined antiemetic treatment with dexamethasone and ginger versus dexamethasone alone

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dc.contributor.authorTavlan, Aybars
dc.contributor.authorTuncer, Sema
dc.contributor.authorErol, Atilla
dc.contributor.authorReish, Ruhiye
dc.contributor.authorAysolmaz, Gokhan
dc.contributor.authorOtelcioglu, Seref
dc.date.accessioned2020-03-26T17:04:04Z
dc.date.available2020-03-26T17:04:04Z
dc.date.issued2006
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground: The aim of this study was to compare the prophylactic effects of dexamethasone plus ginger and dexamethasone alone on postoperative nausea and vomiting (PONV) in patients undergoing thyroidectomy. Methods: One hundred and twenty patients undergoing general anaesthesia for thyroidectomy were enrolled in this randomised, double-blind study. Patients received oral diazepam 10mg with either oral placebo (group I) or 0.5g of ginger (group II) as premedication 1 hour prior to surgery. Standard general anaesthetic techniques and postoperative analgesia were employed. Both group I and group II received intravenous dexamethasone 150 mu g/kg immediately before the induction of anaesthesia. Data were recorded over a 24-hour observation period after surgery. Results: In the dexamethasone-treated group, 14 patients experienced nausea, two patients retched, three patients vomited once, two patients vomited repeatedly, and 14 patients required a rescue antiemetic. In the dexamethasone-plus-ginger-treated group, 12 patients experienced nausea, one patient retched, four patients vomited once, no patients vomited repeatedly, and 13 patients required a rescue antiemetic. Dexamethasone plus ginger, did not significantly reduce nausea and vomiting compared with dexamethasone alone during the observation period. Conclusion: In conclusion, the prophylactic combination of antiemetic treatment with dexamethasone and ginger was not clinically or statistically superior to dexamethasone alone in preventing PONV in patients undergoing thyroidectomy.en_US
dc.identifier.doi10.2165/00044011-200626040-00005en_US
dc.identifier.endpage214en_US
dc.identifier.issn1173-2563en_US
dc.identifier.issn1179-1918en_US
dc.identifier.issue4en_US
dc.identifier.pmid17163253en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage209en_US
dc.identifier.urihttps://dx.doi.org/10.2165/00044011-200626040-00005
dc.identifier.urihttps://hdl.handle.net/20.500.12395/20624
dc.identifier.volume26en_US
dc.identifier.wosWOS:000237687200005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherADIS INT LTDen_US
dc.relation.ispartofCLINICAL DRUG INVESTIGATIONen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.titlePrevention of postoperative nausea and vomiting after thyroidectomy - Combined antiemetic treatment with dexamethasone and ginger versus dexamethasone aloneen_US
dc.typeArticleen_US

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