Prevention of Pain on Injection of Propofol: A Comparison of Lidocaine with Different Doses of Paracetamol

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dc.contributor.authorBorazan, Hale
dc.contributor.authorErdem, Tuba B.
dc.contributor.authorKeçecioğlu, Melahat
dc.contributor.authorOtelcioğlu, Şeref
dc.date.accessioned2020-03-26T18:04:51Z
dc.date.available2020-03-26T18:04:51Z
dc.date.issued2010
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground and objective The aim of this study was to compare the efficacy of pretreatment with paracetamol 0.5 mg kg(-1), 1 mg kg(-1), 2 mg kg(-1) and lidocaine 0.5 mg kg(-1) for prevention of propofol induced pain. Methods In this double-blind, placebo-controlled study, 250 adult patients ASA I or II, scheduled to undergo elective surgery, were randomly assigned into five groups of 50 each. Group P-0.5, group P-1 and group P-2 received 0.5, 1 and 2 mg kg(-1) paracetamol respectively; group L received 0.5 mg kg(-1) lidocaine; and the control group, group C, received isotonic saline pretreatment in the dorsum of the hand, followed by propofol 1 min later. A blinded researcher assessed the patient's pain level via a four-point scale. Results There were no significant differences in patient characteristics among the groups. The incidence of propofol injection pain in all treatment groups was significantly lower than in the control group (P < 0.001). When the paracetamol 0.5 mg kg(-1) group was compared with both the paracetamol 1 mg kg(-1) group (P < 0.01) and the paracetamol 2 mg kg(-1) group (P < 0.001), significant differences were observed. In the lidocaine 0.5 mg kg(-1) group propofol injection pain was significantly reduced compared with the paracetamol 0.5 mg kg(-1) group (P < 0.01). However, in the paracetamol 2 mg kg(-1) group pain was more significantly reduced than in the lidocaine 0.5 mg kg(-1) group (P < 0.001). In the paracetamol 2 mg kg(-1) group the incidence of pain was significantly less than in paracetamol 1 mg kg(-1) group (P < 0.001). Conclusion When given as venous retention pretreatments 1 min before propofol, paracetamol 1 mg kg(-1) and lidocaine 0.5 mg kg(-1) were equally effective in attenuating pain during intravenous (i.v.) injection of propofol whereas pretreatment with paracetamol 2 mg kg(-1) was shown to be the most effective treatment.en_US
dc.identifier.citationBorazan, H., Erdem, T. B., Keçecioğlu, M., Otelcioğlu, Ş., (2010). Prevention of Pain on Injection of Propofol: A Comparison of Lidocaine with Different Doses of Paracetamol. European Journal of Anaesthesiology, 27(3), 253-257. Doi: 10.1097/EJA.0b013e328330eca2
dc.identifier.doi10.1097/EJA.0b013e328330eca2en_US
dc.identifier.endpage257en_US
dc.identifier.issn0265-0215en_US
dc.identifier.issn1365-2346en_US
dc.identifier.issue3en_US
dc.identifier.pmid19696679en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage253en_US
dc.identifier.urihttps://dx.doi.org/10.1097/EJA.0b013e328330eca2
dc.identifier.urihttps://hdl.handle.net/20.500.12395/25183
dc.identifier.volume27en_US
dc.identifier.wosWOS:000275058000006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorBorazan, Hale
dc.institutionauthorErdem, Tuba B.
dc.institutionauthorKeçecioğlu, Melahat
dc.institutionauthorOtelcioğlu, Şeref
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofEuropean Journal of Anaesthesiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectLidocaineen_US
dc.subjectPainen_US
dc.subjectParacetamolen_US
dc.subjectPropofolen_US
dc.titlePrevention of Pain on Injection of Propofol: A Comparison of Lidocaine with Different Doses of Paracetamolen_US
dc.typeArticleen_US

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