Renal Effects of Coronary Artery Bypass Graft Surgery in Diabetic and Non-Diabetic Patients: A Study with Urinary Neutrophil Gelatinase-Associated Lipocalin and Serum Cystatin C

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dc.contributor.authorArun, Oguzhan
dc.contributor.authorCelik, Gulperi
dc.contributor.authorOc, Bahar
dc.contributor.authorUnlu, Ali
dc.contributor.authorCelik, Jale Bengi
dc.contributor.authorOc, Mehmet
dc.contributor.authorDuman, Ates
dc.date.accessioned2020-03-26T19:06:56Z
dc.date.available2020-03-26T19:06:56Z
dc.date.issued2015
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground/Aims: Cardiac surgery and diabetes are major causes of acute kidney injury (AKI). We aimed to investigate the value of urinary neutrophil gelatinase-associated lipocalin (NGAL) and serum cystatin C, as early biomarkers for prediction of AKI in diabetic and nondiabetic adult patients undergoing cardiac surgery. Methods: 15 non-diabetic and 15 diabetic adult patients undergoing cardiac surgery were enrolled. Peri-operative clinical and laboratory variables were recorded. Urinary NGAL, serum cystatin C, serum creatinine (Cre) and blood urea nitrogen (BUN) were evaluated. Results: AKI was detected in 4 patients in non-diabetic group and 12 patients in diabetic group. Urinary NGAL levels of diabetic and non-diabetic patients and serum cystatin C levels of diabetic patients exceed upper normal limits or cut off values much earlier than BUN and Cre. cystatin C levels of non-diabetic patients remain unchanged. Cystatin C and NGAL levels of patients meeting AKI criteria and NGAL levels of patients not meeting AKI criteria exceeded upper normal limits or cut off values much earlier in than BUN and Cre. Conclusions: Measurement of cystatin C level in both diabetic and nondiabetic patients may reveal AKI earlier than NGAL and BUN. In diabetic patients, measurement of urinary NGAL and serum cystatin C levels may indicate AKI signs earlier than BUN and Cre. Copyright (C) 2015 S. Karger AG, Baselen_US
dc.identifier.doi10.1159/000368490en_US
dc.identifier.endpage152en_US
dc.identifier.issn1420-4096en_US
dc.identifier.issn1423-0143en_US
dc.identifier.issue2en_US
dc.identifier.pmid25832128en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage141en_US
dc.identifier.urihttps://dx.doi.org/10.1159/000368490
dc.identifier.urihttps://hdl.handle.net/20.500.12395/32511
dc.identifier.volume40en_US
dc.identifier.wosWOS:000353719300005en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKARGERen_US
dc.relation.ispartofKIDNEY & BLOOD PRESSURE RESEARCHen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAcute kidney injuryen_US
dc.subjectAnesthesiaen_US
dc.subjectCoronary artery bypass graft surgeryen_US
dc.subjectCystatin Cen_US
dc.subjectDiabetesen_US
dc.subjectNeutrophil gelatinase-associated lipocalinen_US
dc.titleRenal Effects of Coronary Artery Bypass Graft Surgery in Diabetic and Non-Diabetic Patients: A Study with Urinary Neutrophil Gelatinase-Associated Lipocalin and Serum Cystatin Cen_US
dc.typeArticleen_US

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