Evaluation of neuroprotection by melatonin against adverse effects of prenatal exposure to a nonsteroidal anti-inflammatory drug during peripheral nerve development

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dc.contributor.authorKeskin, Ilknur
dc.contributor.authorKaplan, Suleyman
dc.contributor.authorKalkan, Serpil
dc.contributor.authorSutcu, Mustafa
dc.contributor.authorUlkay, M. Basak
dc.contributor.authorEsener, O. Burak
dc.date.accessioned2020-03-26T19:05:57Z
dc.date.available2020-03-26T19:05:57Z
dc.date.issued2015
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe potential ability of melatonin to protect against impairment of the fetal peripheral nerve system due to maternal consumption of diclofenac sodium (DS) was investigated. Eighty-four pregnant rats were divided into seven groups: control (CONT), saline administered (PS), DS administered (DS), DS with low-dose melatonin administered (DS + MLT10), DS with high-dose melatonin administered (DS+MLT50), low-dose melatonin administered (MLT10), and high-dose melatonin administered (MLT50). After the pregnancy, six male newborn rats from each group were sacrificed at 4 and 20 weeks of age. Their right sciatic nerves were harvested, and nerve fibers were evaluated using stereological techniques. Mean numbers of myelinated axons, axon cross-section areas and the mean thickness of the myelin sheet were estimated. Four-week-old prenatally DS-exposed rats had significantly fewer axons, a smaller myelinated axonal area, and a thinner myelin sheath compared to CONT group (p < 0.05). Although melatonin at both doses significantly increased axon numbers, only a high dose of melatonin increased the diameter of those axons (p < 0.05). At 20-weeks of age, myelinated axon number in the DS group was not only significantly lower than all other groups (p < 0.05) but also the cross-sectional area of these axons was smaller than all other groups (p < 0.05). There were no differences between the groups regarding the mean thickness of the myelin sheet. The current study indicates that prenatal exposure to DS decreases the number and the diameter of sciatic nerve axons and that melatonin prophylaxis can prevent these effects. (C) 2014 Elsevier Ltd. All rights reserved.en_US
dc.description.sponsorshipScientific and Technical Research Council of Selcuk UniversitySelcuk University [10102002]en_US
dc.description.sponsorshipThis work was supported by a grant from the Scientific and Technical Research Council of Selcuk University [Grant # 10102002]. The authors are grateful to Osman Akdag, MD for skillful technical assistance in the research laboratory; Ender Erdogan, MD, PhD for help with the histological analysis, and Sinan Canan, PhD for assistance during the preparation of the manuscript.en_US
dc.identifier.doi10.1016/j.ijdevneu.2014.12.002en_US
dc.identifier.endpage7en_US
dc.identifier.issn0736-5748en_US
dc.identifier.issn1873-474Xen_US
dc.identifier.pmid25485952en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.ijdevneu.2014.12.002
dc.identifier.urihttps://hdl.handle.net/20.500.12395/32132
dc.identifier.volume41en_US
dc.identifier.wosWOS:000351794000001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPERGAMON-ELSEVIER SCIENCE LTDen_US
dc.relation.ispartofINTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCEen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectNerveen_US
dc.subjectMelatoninen_US
dc.subjectDiclofenac sodiumen_US
dc.subjectNeuroprotectionen_US
dc.subjectPrenatal exposureen_US
dc.titleEvaluation of neuroprotection by melatonin against adverse effects of prenatal exposure to a nonsteroidal anti-inflammatory drug during peripheral nerve developmenten_US
dc.typeArticleen_US

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