Identification and antifungal susceptibility of Candida species isolated from bloodstream infections in Konya, Turkey

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dc.contributor.authorDagi, Hatice Turk
dc.contributor.authorFindik, Duygu
dc.contributor.authorSenkeles, Cigdem
dc.contributor.authorArslan, Ugur
dc.date.accessioned2020-03-26T19:24:35Z
dc.date.available2020-03-26T19:24:35Z
dc.date.issued2016
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground: In this study, our aim was to identify Candida species isolated from bloodstream infections and to determine their susceptibilities to various antifungal agents to demonstrate the local resistance profiles and to guide empirical treatment for clinicians. Methods: Two hundred Candida isolates (95 Candida albicans, 105 non-albicans Candida strains) were included in the study. Candida species were identified by conventional, biochemical and molecular methods. Antifungal susceptibility tests for amphotericin B, fluconazole, voriconazole, posaconazole, caspofungin and anidulafungin were performed with broth microdilution method according to the Clinical and Laboratory Standards Institute M27-A3 document. Results: Of the 200 Candida strains, the most prevalent species were C. albicans (47.5 %), Candida glabrata (18.0 %) and Candida parapsilosis complex (14.0 %). All Candida species except for three (1.5 %) Candida kefyr strains were susceptible to amphotericin B. Only one (2.8 %) C. glabrata was resistant to fluconazole (MIC >= 64 mu g/ml), and the others (97.2 %) exhibited dose-dependent susceptibility. All species, but C. glabrata strains, were susceptible to fluconazole. Resistance to voriconazole, posaconazole, caspofungin and anidulafungin was not detected in any strain. Conclusion: Candida albicans were susceptible to all antifungal drugs. Three C. kefyr strains were resistant to amphotericin B. Only one C. glabrata was resistant to fluconazole. All the strains were susceptible to voriconazole, posaconazole, caspofungin and anidulafungin. In vitro antifungal susceptibility tests should be performed to select of appropriate and effective antifungal therapy, and monitor the development of resistance.en_US
dc.description.sponsorshipCoordinator of Scientific Research Projects at Selcuk University [12401034]en_US
dc.description.sponsorshipThis study was supported by the Coordinator of Scientific Research Projects at Selcuk University (Project Number: 12401034).en_US
dc.identifier.doi10.1186/s12941-016-0153-1en_US
dc.identifier.issn1476-0711en_US
dc.identifier.pmid27245756en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://dx.doi.org/10.1186/s12941-016-0153-1
dc.identifier.urihttps://hdl.handle.net/20.500.12395/33684
dc.identifier.volume15en_US
dc.identifier.wosWOS:000376961100001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBMCen_US
dc.relation.ispartofANNALS OF CLINICAL MICROBIOLOGY AND ANTIMICROBIALSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectCandidaen_US
dc.subjectAnti-fungal susceptibilityen_US
dc.subjectMicrodilution methoden_US
dc.titleIdentification and antifungal susceptibility of Candida species isolated from bloodstream infections in Konya, Turkeyen_US
dc.typeArticleen_US

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