Management of acute mitochondriopathy and encephalopathy syndrome in pediatric intensive care unite: a new clinical entity

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dc.contributor.authorArslan, Şükrü
dc.contributor.authorYorulmaz, Alaaddin
dc.contributor.authorSert, Ahmet
dc.contributor.authorAkın, Fatih
dc.date.accessioned2020-03-26T20:19:57Z
dc.date.available2020-03-26T20:19:57Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractAcute mitochondriopathy and encephalopathy syndrome (AMES) is described differently by different authors in the literature. As a new clinical entity, we aimed to present the clinical signs and symptoms, diagnosis and treatment algorithm of our patients with AMES. 56 patients aged between 2 months and 18 years who were followed up in pediatric intensive care units of Konya Training and Research Hospital and Selcuk University Medical Faculty Hospital, between January 2010 and June 2017 were included. Patients’ data were obtained retrospectively from the intensive care unit patient files. 34 (60.7%) of the patients were male and 22 (39.3%) were female. The median age of our patients was 10.0 months. At the time of admission, 42 (75%) of the patients had fever, 35 (62.5%) vomiting, 27 (48.2%) abnormal behaviour and agitation and 28 (50%) convulsion. The etiological classification of patients with AMES was divided into four groups as infection, metabolic disorder, toxic, and hypoxic-ischemic. 39 (69.6%) patients were found to have infection, 10 (17.9%) patients hypoxia, 7 (12.5%) patients metabolic disorders. AMES occurs rarely, but should be kept in mind in the differential diagnosis of patients with any encephalopathy of unknown origin especially in those with a history of ingestion of drugs, previous viral infection and vomiting. Early recognition and treatment is imperative to reduce morbidity and mortality in children with AMES. © 2019, Belgian Neurological Society.en_US
dc.identifier.citationArslan, Ş., Yorulmaz, A., Sert, A., Akın, F. (2019). Management of Acute Mitochondriopathy and Encephalopathy Syndrome in Pediatric Intensive Care Unite: A New Clinical Entity. Acta Neurologica Belgica, 120, 1115–1121.
dc.identifier.doi10.1007/s13760-019-01125-3en_US
dc.identifier.issn0300-9009en_US
dc.identifier.pmid30887303en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s13760-019-01125-3
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38457
dc.identifier.wosWOS:000570763300011en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorArslan, Şükrü
dc.institutionauthorSert, Ahmet
dc.institutionauthorYorulmaz, Alaaddin
dc.language.isoenen_US
dc.publisherSpringer-Verlag Italia s.r.l.en_US
dc.relation.ispartofActa Neurologica Belgicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectChildrenen_US
dc.subjectEncephalopathyen_US
dc.subjectMitochondrial dysfunctionen_US
dc.subjectTreatment protocolen_US
dc.titleManagement of acute mitochondriopathy and encephalopathy syndrome in pediatric intensive care unite: a new clinical entityen_US
dc.typeArticleen_US

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