Arterial Stiffness and Carotid Intima-Media Thickness in Diabetic Peripheral Neuropathy

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dc.contributor.authorAvci, Ahmet
dc.contributor.authorDemir, Kenan
dc.contributor.authorKaya, Zeynettin
dc.contributor.authorMarakoglu, Kamile
dc.contributor.authorCeylan, Esra
dc.contributor.authorEkmekci, Ahmet Hakan
dc.contributor.authorYilmaz, Ahmet
dc.date.accessioned2020-03-26T18:49:28Z
dc.date.available2020-03-26T18:49:28Z
dc.date.issued2014
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground: We investigated the relationship between peripheral neuropathy and parameters of arterial stiffness and carotid intima media thickness (CIMT) in patients with type 2 diabetes mellitus (T2DM). Material/Methods: The study included 161 patients (80 females and 81 males), 69 of whom had peripheral neuropathy. All patients underwent 24-h blood pressure monitoring, and arterial stiffness parameters were measured. The CIMT was measured using B- mode ultrasonography and patients also underwent transthoracic echocardiographic examination. Results: Patients with peripheral neuropathy, compared with those without it, were older (54.68 +/- 8.35 years vs. 51.04 +/- 7.89 years; p= 0.005) and had T2DM for longer periods (60 vs. 36 months; p= 0.004). Glycated hemoglobin (HbA1c) values (8.55 +/- 1.85 mg/dL vs. 7.30 +/- 1.51 mg/dL; p<0.001), pulse wave velocity (PWV) (7.74 +/- 1.14 m/s vs. 7.15 +/- 1.10 m/s; p= 0.001), CIMT (anterior 0.74 +/- 0.15 mm vs. 0.67 +/- 0.13 mm; p= 0.01), and left ventricular mass (LVM) index (98.68 +/- 26.28 g/m(2) vs. 89.71 +/- 19.70 g/m(2); p= 0.02) were all significantly increased in the group with peripheral neuropathy compared to the group without peripheral neuropathy. We determined that duration of diabetes, HbA1c, and LVM index were predictors of peripheral neuropathy. Conclusions: A significant relationship was found between diabetic neuropathy and increased PWV, a parameter of arterial stiffness, as well as CIMT, a marker of systemic atherosclerosis. Diabetic peripheral neuropathy may be a determinant of subclinical atherosclerosis in T2DM.en_US
dc.identifier.endpage2081en_US
dc.identifier.issn1643-3750en_US
dc.identifier.pmid25351260en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage2074en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/30617
dc.identifier.volume20en_US
dc.identifier.wosWOS:000346197400001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherINT SCIENTIFIC LITERATURE, INCen_US
dc.relation.ispartofMEDICAL SCIENCE MONITORen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectCarotid Intima-Media Thicknessen_US
dc.subjectDiabetes Mellitus, Type 2en_US
dc.subjectDiabetic Neuropathiesen_US
dc.subjectVascular Stiffnessen_US
dc.titleArterial Stiffness and Carotid Intima-Media Thickness in Diabetic Peripheral Neuropathyen_US
dc.typeArticleen_US

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