Increased pulse wave velocity and relationship with inflammation, insulin, and insulin resistance in inflammatory bowel disease

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dc.contributor.authorKorkmaz, Huseyin
dc.contributor.authorSahin, Fatih
dc.contributor.authorIpekci, Suleyman H.
dc.contributor.authorTemel, Tuncer
dc.contributor.authorKebapcilar, Levent
dc.date.accessioned2020-03-26T18:51:05Z
dc.date.available2020-03-26T18:51:05Z
dc.date.issued2014
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective Both ulcerative colitis and Crohn's disease are forms of inflammatory bowel disease (IBD), which is characterized by chronic, progressive inflammation of the gastrointestinal tract. Recent studies have shed new light on the importance of inflammation in the pathogenesis of arterial stiffness. Aim This study aimed to evaluate the relationship between pulse wave velocity (PWV) measurement and biochemical parameters in inactive and active IBD patients without cardiovascular risk factors and perform a comparison with the control group. Materials and methods We enrolled 102 IBD patients without cardiovascular risk factors and 74 matched controls, and evaluated each patient in active and inactive disease periods. All patients completed a standard questionnaire form and we assessed various laboratory parameters. We carried out vascular measurements using a Mobil-O-Graph 24-h pulse wave analysis monitor, an automatic oscillometric device. Results Although cardiovascular risk factors, such as total cholesterol and low-density lipoprotein cholesterol, were significantly lower (P < 0.05) in IBD patients than the controls, 24 h, day and night PWV values, erythrocyte sedimentation rate, C-reactive protein, insulin, homeostasis model assessment of insulin resistance, and homocysteine were higher in patients with active and inactive IBD than the controls (P < 0.05). Multiple linear regression analysis showed that PWV was correlated positively with age and duration of IBD. Conclusion This study showed increased PWV, homocysteine, erythrocyte sedimentation rate, C-reactive protein, insulin, and homeostasis model assessment of insulin resistance in patients with active and inactive IBD and provides evidence of the potential contribution of inflammation and inflammation-related factors toward arterial stiffening independent from conventional cardiovascular risk factors. (C) 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins.en_US
dc.description.provenanceMade available in DSpace on 2020-03-26T18:51:05Z (GMT). No. of bitstreams: 0 Previous issue date: 2014en
dc.identifier.doi10.1097/MEG.0000000000000104en_US
dc.identifier.endpage732en_US
dc.identifier.issn0954-691Xen_US
dc.identifier.issn1473-5687en_US
dc.identifier.issue7en_US
dc.identifier.pmid24901818en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage725en_US
dc.identifier.urihttps://dx.doi.org/10.1097/MEG.0000000000000104
dc.identifier.urihttps://hdl.handle.net/20.500.12395/30922
dc.identifier.volume26en_US
dc.identifier.wosWOS:000337151300007en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLIPPINCOTT WILLIAMS & WILKINSen_US
dc.relation.ispartofEUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectarterial stiffnessen_US
dc.subjecthomocysteineen_US
dc.subjectinflammatory bowel diseaseen_US
dc.subjectinsulin resistanceen_US
dc.subjectpulse wave velocityen_US
dc.titleIncreased pulse wave velocity and relationship with inflammation, insulin, and insulin resistance in inflammatory bowel diseaseen_US
dc.typeArticleen_US

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