Investigation of 1377C/T polymorphism of the Toll-like receptor 3 among patients with chronic hepatitis B

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dc.contributor.authorGoktas, Emine Firat
dc.contributor.authorBulut, Cemal
dc.contributor.authorGoktas, Mustafa Tugrul
dc.contributor.authorOzer, Erdem Kamil
dc.contributor.authorKaraca, Ragip Ozgur
dc.contributor.authorKinikli, Sami
dc.contributor.authorDemiroz, Ali Pekcan
dc.date.accessioned2020-03-26T19:24:47Z
dc.date.available2020-03-26T19:24:47Z
dc.date.issued2016
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe immunopathogenesis of chronic hepatitis B (CHB) has not been clarified yet. Toll-like receptors (TLR) are a receptor family that initiates immunity with exogenous-endogenous ligands and plays a role in the pathogenesis of infections. In this study, we aimed to investigate the frequency of TLR 3 1377C/T (rs3775290) polymorphism and its role in patients with CHB. We included 50 healthy individuals as control group and 73 active and 43 inactive hepatitis B patients. All DNA samples were isolated from blood samples. For the detection of TLR 3 1377C/T single-nucleotide polymorphism, restriction fragment length polymorphism was used. A statistically significant difference was determined in Hepatitis B virus (HBV) DNA levels of CHB patients with the CC, CT, and TT genotypes (p = 0.013). The highest levels of HBV DNA were detected in individuals with TT genotypes. Additionally, the frequency of CC genotype was higher in the active CHB patients compared with that of the inactive CHB patients (p = 0.044). No statistically significant difference in TLR 3 1377C/T polymorphism was detected between healthy controls and the hepatitis B patients (p = 0.342). In conclusion, HBV DNA level was higher in the individuals with TT genotype, and CC genotype was more frequent in the active CHB patients. These results suggest a possible association between CHB and TLR 3 gene (1377C/T) polymorphism.en_US
dc.identifier.doi10.1139/cjm-2016-0129en_US
dc.identifier.endpage622en_US
dc.identifier.issn0008-4166en_US
dc.identifier.issn1480-3275en_US
dc.identifier.issue7en_US
dc.identifier.pmid27314608en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage617en_US
dc.identifier.urihttps://dx.doi.org/10.1139/cjm-2016-0129
dc.identifier.urihttps://hdl.handle.net/20.500.12395/33726
dc.identifier.volume62en_US
dc.identifier.wosWOS:000378785100009en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherCANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESSen_US
dc.relation.ispartofCANADIAN JOURNAL OF MICROBIOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectchronic hepatitis Ben_US
dc.subjectToll-like receptorsen_US
dc.subjectsingle-nucleotide polymorphismen_US
dc.titleInvestigation of 1377C/T polymorphism of the Toll-like receptor 3 among patients with chronic hepatitis Ben_US
dc.typeArticleen_US

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