Increased arterial stiffness and its relationship with inflammation, insulin, and insulin resistance in celiac disease

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dc.contributor.authorKorkmaz, Huseyin
dc.contributor.authorSozen, Mehmet
dc.contributor.authorKebapcilar, Levent
dc.date.accessioned2020-03-26T19:06:07Z
dc.date.available2020-03-26T19:06:07Z
dc.date.issued2015
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjectiveCeliac disease (CD) is a lifelong, chronic, immune-mediated, inflammatory small bowel disorder, precipitated by exposure to dietary gluten and related proteins in genetically predisposed individuals. Recent studies have shed new light on the importance of inflammation in the pathogenesis of arterial stiffness. The aim of this study was to evaluate arterial stiffness using pulse wave velocity (PWV) in adult CD patients without cardiovascular risk factors in comparison with a control group.Patients and methodsA total of 58 patients with CD without cardiovascular risk factors and age-matched and sex-matched healthy controls were enrolled in the study. All patients completed a standard questionnaire form, and various laboratory parameters were assessed. Vascular measurements, including PWV, were carried out using a Mobil-O-Graph 24-h pulse wave analysis monitor, an automatic oscillometric device.ResultsAlthough cardiovascular risk factors, such as low-density lipoprotein cholesterol and triglyceride, were significantly lower (P<0.05) in celiac patients than in controls, the erythrocyte sedimentation rate, C-reactive protein, insulin, homeostasis model assessment of insulin resistance, homocysteine, and 24h, day, and night PWV values were higher in patients with CD than in controls (P<0.05). A multiple linear regression analysis showed that PWV was correlated positively with age and the duration of CD.ConclusionThis study found increased arterial stiffness, homocysteine, erythrocyte sedimentation rate, C-reactive protein, insulin, and homeostasis model assessment of insulin resistance in patients with CD and provides evidence for the potential contribution of these parameters and inflammation toward arterial stiffening, independent of conventional cardiovascular risk factors.en_US
dc.identifier.doi10.1097/MEG.0000000000000437en_US
dc.identifier.endpage1199en_US
dc.identifier.issn0954-691Xen_US
dc.identifier.issn1473-5687en_US
dc.identifier.issue10en_US
dc.identifier.pmid26181110en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1193en_US
dc.identifier.urihttps://dx.doi.org/10.1097/MEG.0000000000000437
dc.identifier.urihttps://hdl.handle.net/20.500.12395/32232
dc.identifier.volume27en_US
dc.identifier.wosWOS:000361197200013en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLIPPINCOTT WILLIAMS & WILKINSen_US
dc.relation.ispartofEUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectarterial stiffnessen_US
dc.subjectceliac diseaseen_US
dc.subjecthomocysteineen_US
dc.subjectinsulin resistanceen_US
dc.subjectpulse wave velocityen_US
dc.titleIncreased arterial stiffness and its relationship with inflammation, insulin, and insulin resistance in celiac diseaseen_US
dc.typeArticleen_US

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