Multiple pharmacological approaches on hydroalcoholic extracts from different parts of Cynoglossum creticum Mill. (Boraginaceae)
Yükleniyor...
Dosyalar
Tarih
2019
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
TAYLOR & FRANCIS LTD
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Cynoglossum creticum Mill (Boraginaceae) is used traditionally as a remedy to manage several human ailments. In this context, the present study aimed to perform multiple pharmacological investigations on the hydroalcoholic extracts prepared from Cynoglossum roots and aerial parts (leaves and flowers). We evaluated the antioxidant and enzyme inhibitory (against cholinesterases, alpha-glucosidase, alpha-amylase, lipase and tyrosinase) activity of the extracts. The protective effect(s) of the extracts on cardiomyocyte C2C12 and intestinal HCT116 cell lines challenged with hydrogen peroxide (H2O2) was studied. We found that the aerial parts harbored the highest amount of phenolic compounds. Generally, aerial parts showed significant antioxidant and enzyme inhibitory effects. Leaves exhibited the best lipase inhibitory activity (173.15 mgOE/g extract), followed by flowers and roots. The root and aerial extracts were equally able to blunt intracellular H2O2 induced reactive oxygen species production from both C2C12 and HCT116 cell lines. Both cells lines could be treated with scalar concentrations of root and flower extracts in the range 50-300 mu g/mL without interferences on cell viability. In conclusion, the present study showed protective effects exerted by Cynoglossum extracts, which could serve as a foundation for the development of pharmaceuticals and nutraceuticals derived from Cynoglossum.
Açıklama
Anahtar Kelimeler
Cynoglossum, HPLC-PDA, Antioxidant, Enzyme inhibition, Cell assays, Natural agents, Cardiomyocyte
Kaynak
PLANT BIOSYSTEMS
WoS Q Değeri
Q2
Scopus Q Değeri
Q2
Cilt
153
Sayı
5
Künye
Menghini, L., Ferrante, C., Zengin, G., Mahomoodally, M. F., Leporini, L., Locatelli, M., Cacciagrano, F., Recinella, L., Chiavaroli, A., Leone, S., Brunetti, L., Orlando, G. (2019). Multiple Pharmacological Approaches on Hydroalcoholic Extracts from Different Parts of Cynoglossum creticum Mill.(Boraginaceae). Plant Biosystems-An International Journal Dealing with all Aspects of Plant Biology, 153(5), 633-639.
