Multiple pharmacological approaches on hydroalcoholic extracts from different parts of Cynoglossum creticum Mill. (Boraginaceae)

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dc.authorid0000-0002-0840-825X
dc.contributor.authorMenghini, Luigi
dc.contributor.authorFerrante, Claudio
dc.contributor.authorZengin, Gökhan
dc.contributor.authorMahomoodally, Mohamad Fawzi
dc.contributor.authorLeporini, Lidia
dc.contributor.authorLocatelli, Marcello
dc.contributor.authorCacciagrano, Francesco
dc.contributor.authorRecinella, Lucia
dc.contributor.authorChiavaroli, Annalisa
dc.contributor.authorLeone, Sheila
dc.contributor.authorBrunetti, Luigi
dc.contributor.authorOrlando, Giustino
dc.date.accessioned2020-03-26T20:15:20Z
dc.date.available2020-03-26T20:15:20Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Fen Fakültesi, Biyoloji Bölümüen_US
dc.description.abstractCynoglossum creticum Mill (Boraginaceae) is used traditionally as a remedy to manage several human ailments. In this context, the present study aimed to perform multiple pharmacological investigations on the hydroalcoholic extracts prepared from Cynoglossum roots and aerial parts (leaves and flowers). We evaluated the antioxidant and enzyme inhibitory (against cholinesterases, alpha-glucosidase, alpha-amylase, lipase and tyrosinase) activity of the extracts. The protective effect(s) of the extracts on cardiomyocyte C2C12 and intestinal HCT116 cell lines challenged with hydrogen peroxide (H2O2) was studied. We found that the aerial parts harbored the highest amount of phenolic compounds. Generally, aerial parts showed significant antioxidant and enzyme inhibitory effects. Leaves exhibited the best lipase inhibitory activity (173.15 mgOE/g extract), followed by flowers and roots. The root and aerial extracts were equally able to blunt intracellular H2O2 induced reactive oxygen species production from both C2C12 and HCT116 cell lines. Both cells lines could be treated with scalar concentrations of root and flower extracts in the range 50-300 mu g/mL without interferences on cell viability. In conclusion, the present study showed protective effects exerted by Cynoglossum extracts, which could serve as a foundation for the development of pharmaceuticals and nutraceuticals derived from Cynoglossum.en_US
dc.identifier.citationMenghini, L., Ferrante, C., Zengin, G., Mahomoodally, M. F., Leporini, L., Locatelli, M., Cacciagrano, F., Recinella, L., Chiavaroli, A., Leone, S., Brunetti, L., Orlando, G. (2019). Multiple Pharmacological Approaches on Hydroalcoholic Extracts from Different Parts of Cynoglossum creticum Mill.(Boraginaceae). Plant Biosystems-An International Journal Dealing with all Aspects of Plant Biology, 153(5), 633-639.
dc.identifier.doi10.1080/11263504.2018.1527790en_US
dc.identifier.endpage639en_US
dc.identifier.issn1126-3504en_US
dc.identifier.issn1724-5575en_US
dc.identifier.issue5en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage633en_US
dc.identifier.urihttps://dx.doi.org/10.1080/11263504.2018.1527790
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38018
dc.identifier.volume153en_US
dc.identifier.wosWOS:000476897700001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorZengin, Gökhan
dc.language.isoenen_US
dc.publisherTAYLOR & FRANCIS LTDen_US
dc.relation.ispartofPLANT BIOSYSTEMSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectCynoglossumen_US
dc.subjectHPLC-PDAen_US
dc.subjectAntioxidanten_US
dc.subjectEnzyme inhibitionen_US
dc.subjectCell assaysen_US
dc.subjectNatural agentsen_US
dc.subjectCardiomyocyteen_US
dc.titleMultiple pharmacological approaches on hydroalcoholic extracts from different parts of Cynoglossum creticum Mill. (Boraginaceae)en_US
dc.typeArticleen_US

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