Cooling and response to hydrogen peroxide in human saphenous vein: role of the endothelium

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dc.contributor.authorSahin, AS
dc.contributor.authorAtalik, KE
dc.contributor.authorSahin, TK
dc.contributor.authorDogan, N
dc.date.accessioned2020-03-26T16:56:45Z
dc.date.available2020-03-26T16:56:45Z
dc.date.issued2005
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractIn the present work we studied the responses of human saphenous vein to H2O2 and effects of moderate cooling on these responses with analysis of the role of endothelium. H2O2 (10(-7)-10(-2) m) induced concentration-dependent contraction in the intact human saphenous vein strips at both temperatures. At 28 degrees C, the maximal contraction induced by H2O2 was significantly lower than that at 37 degrees C. Compared with intact strips, the sensitivity and the maximal contraction to H2O2 were significantly enhanced in endothelium-denuded strips at 37 and 28 degrees C. However, pD(2) values and maximal contractions were not significantly different in endothelium-denuded strips at different temperatures. Pretreatment with N-G-nitro-L-arginine methyl ester (L-NAME) increased significantly the maximal contraction and sensitivity to H2O2 at 37 and 28 degrees C. The contractions increased by L-NAME were restored by the pre-incubation Of L-arginine (10(-3) m) at every temperature studied. The contractile responses of intact human saphenous veins to H2O2 were reduced significantly by 10(-5) m indomethacin at both temperatures. Our results suggest that H2O2-induced contraction of human saphenous vein are mediated by its direct effect on the smooth muscle and by the generation of products of the cyclooxygenase pathway from the endothelium. Signalling pathways of these contractile effects are the same at 3 7 and 28 degrees C. Under normal temperature conditions, the contraction to H2O2 is possibly modulated by endothelial nitric oxide. Cooling reduces the contraction to H2O2 by increasing release of nitric oxide.en_US
dc.identifier.doi10.1111/j.1472-8206.2005.00330.xen_US
dc.identifier.endpage346en_US
dc.identifier.issn0767-3981en_US
dc.identifier.issn1472-8206en_US
dc.identifier.issue3en_US
dc.identifier.pmid15910658en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage341en_US
dc.identifier.urihttps://dx.doi.org/10.1111/j.1472-8206.2005.00330.x
dc.identifier.urihttps://hdl.handle.net/20.500.12395/19642
dc.identifier.volume19en_US
dc.identifier.wosWOS:000229584000009en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWILEYen_US
dc.relation.ispartofFUNDAMENTAL & CLINICAL PHARMACOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectcoolingen_US
dc.subjectendotheliumen_US
dc.subjecthuman saphenous veinen_US
dc.subjecthydrogen peroxide (H2O2)en_US
dc.titleCooling and response to hydrogen peroxide in human saphenous vein: role of the endotheliumen_US
dc.typeArticleen_US

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