Comparative Cytotoxicity of Glycyrrhiza glabra Roots from Different Geographical Origins Against Immortal Human Keratinocyte (HaCaT), Lung Adenocarcinoma (A549) and Liver Carcinoma (HepG2) Cells

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dc.contributor.authorBasar, Norazah
dc.contributor.authorOridupa, Olayinka Ayotunde
dc.contributor.authorRitchie, Kenneth J.
dc.contributor.authorNahar, Lutfun
dc.contributor.authorOsman, Nashwa Mostafa M.
dc.contributor.authorStafford, Angela
dc.contributor.authorKushiev, Habibjon
dc.date.accessioned2020-03-26T19:01:26Z
dc.date.available2020-03-26T19:01:26Z
dc.date.issued2015
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractGlycyrrhiza glabra L. (Fabaceae), commonly known as liquorice', is a well-known medicinal plant. Roots of this plant have long been used as a sweetening and flavouring agent in food and pharmaceutical products, and also as a traditional remedy for cough, upper and lower respiratory ailments, kidney stones, hepatitis C, skin disorder, cardiovascular diseases, diabetes, gastrointestinal ulcers and stomach ache. Previous pharmacological and clinical studies have revealed its antitussive, antiinflammatory, antiviral, antimicrobial, antioxidant, immunomodulatory, hepatoprotective and cardioprotective properties. While glycyrrhizin, a sweet-tasting triterpene saponin, is the principal bioactive compound, several bioactive flavonoids and isoflavonoids are also present in the roots of this plant. In the present study, the cytotoxicity of the methanol extracts of nine samples of the roots of G.glabra, collected from various geographical origins, was assessed against immortal human keratinocyte (HaCaT), lung adenocarcinoma (A549) and liver carcinoma (HepG2) cell lines using the in vitro 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazoliumbromide cell toxicity/viability assay. Considerable variations in levels of cytotoxicity were observed among various samples of G.glabra. Copyright (c) 2015 John Wiley & Sons, Ltd.en_US
dc.description.sponsorshipMinistry of Education, Malaysiaen_US
dc.description.sponsorshipOne of the authors (N.B.) is thankful to the Ministry of Education, Malaysia, for the financial support. The authors thank Dr Kehinde Ross, LJMU, for the provision of the HaCaT cell line.en_US
dc.identifier.doi10.1002/ptr.5329en_US
dc.identifier.endpage948en_US
dc.identifier.issn0951-418Xen_US
dc.identifier.issn1099-1573en_US
dc.identifier.issue6en_US
dc.identifier.pmid25779384en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage944en_US
dc.identifier.urihttps://dx.doi.org/10.1002/ptr.5329
dc.identifier.urihttps://hdl.handle.net/20.500.12395/31943
dc.identifier.volume29en_US
dc.identifier.wosWOS:000355843200021en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWILEYen_US
dc.relation.ispartofPHYTOTHERAPY RESEARCHen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectGlycyrrhiza glabraen_US
dc.subjectliquoriceen_US
dc.subjectFabaceaeen_US
dc.subjectcytotoxicityen_US
dc.subjectcanceren_US
dc.subjectMTTen_US
dc.titleComparative Cytotoxicity of Glycyrrhiza glabra Roots from Different Geographical Origins Against Immortal Human Keratinocyte (HaCaT), Lung Adenocarcinoma (A549) and Liver Carcinoma (HepG2) Cellsen_US
dc.typeArticleen_US

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