The role of cord blood IGF-I levels in preterm osteopenia

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dc.contributor.authorAtabek, ME
dc.contributor.authorPirgon, O
dc.contributor.authorYorulmaz, A
dc.contributor.authorKurtoglu, S
dc.date.accessioned2020-03-26T17:04:38Z
dc.date.available2020-03-26T17:04:38Z
dc.date.issued2006
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective: Osteopenia is a frequent condition in preterm infants. This prospective study was designed to assess the relationship between cord blood insulin-like growth factor-I (IGF-I) levels and bone mineralization in healthy premature infants. Methods: Twenty preterm infants (ten males and ten females) were studied. We determined the bone mineral density (BMD) and bone mineral content (BMC) of healthy premature infants by dual-energy X-ray absorptiometry and also studied the correlation between IGF-I and other parameters and the influence of cord blood IGF-I concentrations on bone mineralization in these infants. Results: The mean concentration of IGF-I was 13.6 +/- 16.9 ng/ml and BMD and BMC were 0.249 +/- 0.06 g/cm(2) and 3.09 +/- 1.18 g, respectively. Cord serum levels of IGF-I had significantly positive correlations with BMD (r = 0.605, p = 0.008), but not BMC (r = 0.242, p = 0.367). In stepwise regression analysis, IGF-I emerged as a significant predictor of BMD (beta = 0.595, p 0.015) contributing to 35.4% of its variability. Conclusion: We found a relationship between cord blood IGF-I and BMD in preterm neonates, suggesting that even within an unremarkable population, IGF-I might be important to ensuring bone health.en_US
dc.identifier.endpage257en_US
dc.identifier.issn0334-018Xen_US
dc.identifier.issue3en_US
dc.identifier.pmid16607926en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage253en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/20743
dc.identifier.volume19en_US
dc.identifier.wosWOS:000236479400010en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherFREUND PUBLISHING HOUSE LTDen_US
dc.relation.ispartofJOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISMen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectpreterm infanten_US
dc.subjectosteopeniaen_US
dc.subjectinsulin-like growth factor-Ien_US
dc.titleThe role of cord blood IGF-I levels in preterm osteopeniaen_US
dc.typeArticleen_US

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