Opposite effects of zinc and melatonin on thyroid hormones in rats

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dc.contributor.authorBaltaci, AK
dc.contributor.authorMogulkoc, R
dc.contributor.authorKul, A
dc.contributor.authorBediz, CS
dc.contributor.authorUgur, A
dc.date.accessioned2020-03-26T16:55:23Z
dc.date.available2020-03-26T16:55:23Z
dc.date.issued2004
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe present study was conducted to investigate how thyroid function in rats is affected by administration of 3 mg per kg per day of zinc and/or melatonin. The study was conducted with 40 Sprague-Dawley adult male rats equally divided into four groups: 1 (controls), 2 (zinc-only), 3 (melatonin-only) and 4 (zinc- and melatonin-supplemented). The supplementation was continued for 4 weeks after which the animals were sacrificed and plasma samples were obtained for determination of zinc, melatonin, free- and total triiodothyronine (T3), thyroxine (T4) and thyroid-stimulating hormone (TSH) levels. The free T3, T4 and TSH levels were lower in the melatonin group than in all other groups (P<0.01), while free- and total T3 levels were higher in the zinc group (P<0.01). The group that received zinc and melatonin combined had free thyroid hormone levels higher than the only melatonin group. These results show that melatonin has a thyroid function suppressing action, just the opposite to the actions of zinc. When zinc is administered along with melatonin, its thyroid function suppression is diminished. (C) 2003 Elsevier Ireland Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.tox.2003.09.001en_US
dc.identifier.endpage75en_US
dc.identifier.issn0300-483Xen_US
dc.identifier.issue1en_US
dc.identifier.pmid14698569en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage69en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.tox.2003.09.001
dc.identifier.urihttps://hdl.handle.net/20.500.12395/19151
dc.identifier.volume195en_US
dc.identifier.wosWOS:000188536300006en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherELSEVIER IRELAND LTDen_US
dc.relation.ispartofTOXICOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectzincen_US
dc.subjectmelatoninen_US
dc.subjectthyroid hormone functionen_US
dc.subjectratsen_US
dc.titleOpposite effects of zinc and melatonin on thyroid hormones in ratsen_US
dc.typeArticleen_US

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