Pharmacokinetics of florfenicol in the plasma of Japanese quail

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dc.contributor.authorKoc, F.
dc.contributor.authorUney, K.
dc.contributor.authorOzturk, M.
dc.contributor.authorKadioglu, Y.
dc.contributor.authorAtila, A.
dc.date.accessioned2020-03-26T17:39:38Z
dc.date.available2020-03-26T17:39:38Z
dc.date.issued2009
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractAIM: To determine the pharmacokinetics and bioavailability of florfenicol in the plasma of healthy Japanese quail (Coturnix japonica). METHODS: Sixty-five quail were given an I/V and I/M dose of florfenicol at 30 mg/kg bodyweight (BW). A two-period sequential design was used, with a wash-out period of 2 weeks between the different routes of administration. Concentrations of florfenicol in plasma were determined using high-performance liquid chromatography (HPLC). RESULTS: A naive pooled data analysis approach for the plasma concentration-time profile of florfenicol was found to fit a non-compartmental open model. After I/V administration, the mean residence time (MRT), mean volume of distribution at steady state (V(ss)), and total body clearance of florfenicol were 12.0 (SD 0.37) h, 8.7 (SD 0.22) L/kg, and 1.3 (SD 0.08) L/h/kg, respectively. After I/M injection, the MRT, mean absorption time (MAT), and bioavailability were 12.3 (SD 0.37) h, 0.2 (SD 0.02) h, and 79.1 (SD 1.79)%, respectively. CONCLUSIONS: The time for the concentration of florfenicol to fall below the probable effective concentration of 1 mu g/ml of approximately 10 h is sufficient for the minimum inhibitory concentration needed for many bacterial isolates. Further pharmacodynamic studies in quail are needed to evaluate a suitable dosage regimen.en_US
dc.identifier.doi10.1080/00480169.2009.64734en_US
dc.identifier.endpage391en_US
dc.identifier.issn0048-0169en_US
dc.identifier.issue6en_US
dc.identifier.pmid19966901en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage388en_US
dc.identifier.urihttps://dx.doi.org/10.1080/00480169.2009.64734
dc.identifier.urihttps://hdl.handle.net/20.500.12395/23758
dc.identifier.volume57en_US
dc.identifier.wosWOS:000273349900014en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherNEW ZEALAND VETERINARY ASSOC INCen_US
dc.relation.ispartofNEW ZEALAND VETERINARY JOURNALen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectPharmacokineticen_US
dc.subjectflorfenicolen_US
dc.subjectquailen_US
dc.subjectplasmaen_US
dc.subjectbioavailabilityen_US
dc.titlePharmacokinetics of florfenicol in the plasma of Japanese quailen_US
dc.typeArticleen_US

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