Leptin, NPY, Melatonin and Zinc Levels in Experimental Hypothyroidism and Hyperthyroidism: The Relation to Zinc

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dc.contributor.authorBaltacı, Abdülkerim Kasım
dc.contributor.authorMoğulkoç, Rasim
dc.date.accessioned2020-03-26T19:42:00Z
dc.date.available2020-03-26T19:42:00Z
dc.date.issued2017
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractSince zinc mediates the effects of many hormones or is found in the structure of numerous hormone receptors, zinc deficiency leads to various functional impairments in the hormone balance. And also thyroid hormones have important activity on metabolism and feeding. NPY and leptin are affective on food intake and regulation of appetite. The present study is conducted to determine how zinc supplementation and deficiency affect thyroid hormones (free and total T3 and T4), melatonin, leptin, and NPY levels in thyroid dysfunction in rats. The experiment groups in the study were formed as follows: Control (C); Hypothyroidism (PTU); Hypothyroidism+Zinc (PTU+Zn); Hypothyroidism+Zinc deficient; Hyperthyroidism (H); Hyperthyroidism+Zinc (H+Zn); and Hyperthyroidism+Zinc deficient. Thyroid hormone parameters (FT3, FT4, TT3, and TT4) were found to be reduced in hypothyroidism groups and elevated in the hyperthyroidism groups. Melatonin values increased in hyperthyroidism and decreased in hypothyroidism. Leptin and NPY levels both increased in hypo- and hyperthyroidism. Zinc levels, on the other hand, decreased in hypothyroidism and increased in hyperthyroidism. Zinc supplementation, particularly when thyroid function is impaired, has been demonstrated to markedly prevent these changes.en_US
dc.description.sponsorshipSelcuk University, Scientific Research CouncilSelcuk University [2002086]en_US
dc.description.sponsorshipThis study was supported by a grant from the Selcuk University, Scientific Research Council (Grant number is 2002086).en_US
dc.identifier.doi10.1007/s10528-017-9791-zen_US
dc.identifier.endpage233en_US
dc.identifier.issn0006-2928en_US
dc.identifier.issn1573-4927en_US
dc.identifier.issue3en_US
dc.identifier.pmid28097455en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage223en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s10528-017-9791-z
dc.identifier.urihttps://hdl.handle.net/20.500.12395/35256
dc.identifier.volume55en_US
dc.identifier.wosWOS:000401733600004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSPRINGER/PLENUM PUBLISHERSen_US
dc.relation.ispartofBIOCHEMICAL GENETICSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectThyroid hormonesen_US
dc.subjectMelatoninen_US
dc.subjectLeptinen_US
dc.subjectNPYen_US
dc.subjectZincen_US
dc.subjectRaten_US
dc.titleLeptin, NPY, Melatonin and Zinc Levels in Experimental Hypothyroidism and Hyperthyroidism: The Relation to Zincen_US
dc.typeArticleen_US

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