Untargeted metabolomic profiling of three Crataegus species (hawthorn) and their in vitro biological activities

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dc.contributor.authorRocchetti, Gabriele
dc.contributor.authorSenizza, Biancamaria
dc.contributor.authorZengin, Gökhan
dc.contributor.authorMahomodally, Mohamad Fawzi
dc.contributor.authorSenkardes, Ismail
dc.contributor.authorLobine, Devina
dc.contributor.authorLucini, Luigi
dc.date.accessioned2020-03-26T20:19:42Z
dc.date.available2020-03-26T20:19:42Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBACKGROUND In this investigation, the chemical and biological profiles of three Turkish Crataegus species (Crataegus orientalis, Crataegus szovitsii and Crataegus tanacetifolia) were studied in order to provide the first comprehensive characterization and their health-promoting potential. In this respect, polyphenolic profiles were evaluated using ultrahigh-performance liquid chromatography-quadrupole time-of-flight mass spectrometry. The in vitro antioxidant activities of the Crataegus samples were evaluated by using free-radical scavenging, phosphomolybdenum, ferrous-ion chelating, and reducing power assays. The inhibitory activities against alpha-glucosidase, amylase, cholinesterases (acetylcholinesterase (AChE) and butyrylcholinesterase (BChE)), and tyrosinase were also established. RESULTS The untargeted metabolomic approach highlighted the effect of both extraction types and species on the phenolic profiles of different Crateagus tissues (i.e. leaves and twigs). The methanolic extracts showed the maximum radical scavenging and reducing activity in all test systems, whereas for ferrous-ion chelating assays the decocted and infused extracts showed the highest activity. Only the methanolic extracts were effective against AChE and BChE. The extract tested showed remarkable inhibitory effects against tyrosinase and alpha-glucosidase, whereas all the extracts exhibited modest inhibition against alpha-amylase. Overall, the twig extracts of the three species studied showed superior antioxidant and enzyme inhibitory activities. CONCLUSION On the basis of these results, the three Crataegus species can be classified as potent bioresources for high-value phytochemicals, which warrant further investigations for developing novel nutraceuticals. (c) 2019 Society of Chemical Industryen_US
dc.identifier.doi10.1002/jsfa.10216en_US
dc.identifier.issn0022-5142en_US
dc.identifier.issn1097-0010en_US
dc.identifier.pmid31849067en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://dx.doi.org/10.1002/jsfa.10216
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38370
dc.identifier.wosWOS:000508953400001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWILEYen_US
dc.relation.ispartofJOURNAL OF THE SCIENCE OF FOOD AND AGRICULTUREen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjecthawthornen_US
dc.subjectantioxidanten_US
dc.subjectenzyme inhibitoren_US
dc.subjectphytochemicalsen_US
dc.titleUntargeted metabolomic profiling of three Crataegus species (hawthorn) and their in vitro biological activitiesen_US
dc.typeArticleen_US

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