Immunomodulatory properties of various natural compounds and essential oils through modulation of human cellular immune response
Küçük Resim Yok
Tarih
2016
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
ELSEVIER SCIENCE BV
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Randomly selected essential oils and some terpene and phenolic derivatives were evaluated for their ability to modulate human cellular immune responses using various inflammatory parameters including reactive oxygen species (ROS) generation from whole blood phagocytes and isolated polymorphonuclear neutrophils (PMNs), proliferation of T-cells, IL-2. and TNF-alpha cytokine production. The essential oils from Foeniculum vulgare, Saturea cuneifolia, and Origanum munitiflorum inhibited ROS produced from whole blood phagocytes, while thymol, carvacrol, rosmarinic acid, caffeic acid, quercetin, and kaempferol glycoside potently inhibited the ROS production from whole blood as well as from isolated PMNs, among which caffeic acid, quercetin, and kaempferol glycoside exhibited a better inhibitory effect than that of ibuprofen. The compounds rosmarinic acid, caffeic acid, quercetin, kaempferol glycoside, genistein, and apigenin (IC50 7.0 +/- 0.5, <3.12, <3.12, 4.3 +/- 1.0, 5.8 +/- 0.5, and <3.12 mu g/mL) were found to exert potent inhibition on proliferation of T -cells. On the other hand, quercetin (IC50 2.9 +/- 0.3 mu g/mL) and apigenin (IC50 <1.0 mu g/mL), were also found to be the potent inhibitor of IL-2 cytokine. The essential oils of Mentha species, and compounds quercetin and apigenin were found to potently inhibit the production of pro inflammatory cytokine TNF-alpha. The results indicated that essential oils and phenolics might be considered as promising immunomodulatory agents. (C) 2015 Elsevier B.V. All rights reserved.
Açıklama
Anahtar Kelimeler
Immunomodulatory activity, Essential oil, Natural compound, TNF-alpha, Cytokine, ROS, T-cell proliferation
Kaynak
INDUSTRIAL CROPS AND PRODUCTS
WoS Q Değeri
Q1
Scopus Q Değeri
Q1
Cilt
81
