Immunomodulatory properties of various natural compounds and essential oils through modulation of human cellular immune response

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dc.contributor.authorOrhan, Ilkay Erdogan
dc.contributor.authorMesaik, M. Ahmed
dc.contributor.authorJabeen, Almas
dc.contributor.authorKan, Yuksel
dc.date.accessioned2020-03-26T19:24:38Z
dc.date.available2020-03-26T19:24:38Z
dc.date.issued2016
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractRandomly selected essential oils and some terpene and phenolic derivatives were evaluated for their ability to modulate human cellular immune responses using various inflammatory parameters including reactive oxygen species (ROS) generation from whole blood phagocytes and isolated polymorphonuclear neutrophils (PMNs), proliferation of T-cells, IL-2. and TNF-alpha cytokine production. The essential oils from Foeniculum vulgare, Saturea cuneifolia, and Origanum munitiflorum inhibited ROS produced from whole blood phagocytes, while thymol, carvacrol, rosmarinic acid, caffeic acid, quercetin, and kaempferol glycoside potently inhibited the ROS production from whole blood as well as from isolated PMNs, among which caffeic acid, quercetin, and kaempferol glycoside exhibited a better inhibitory effect than that of ibuprofen. The compounds rosmarinic acid, caffeic acid, quercetin, kaempferol glycoside, genistein, and apigenin (IC50 7.0 +/- 0.5, <3.12, <3.12, 4.3 +/- 1.0, 5.8 +/- 0.5, and <3.12 mu g/mL) were found to exert potent inhibition on proliferation of T -cells. On the other hand, quercetin (IC50 2.9 +/- 0.3 mu g/mL) and apigenin (IC50 <1.0 mu g/mL), were also found to be the potent inhibitor of IL-2 cytokine. The essential oils of Mentha species, and compounds quercetin and apigenin were found to potently inhibit the production of pro inflammatory cytokine TNF-alpha. The results indicated that essential oils and phenolics might be considered as promising immunomodulatory agents. (C) 2015 Elsevier B.V. All rights reserved.en_US
dc.identifier.doi10.1016/j.indcrop.2015.11.088en_US
dc.identifier.endpage122en_US
dc.identifier.issn0926-6690en_US
dc.identifier.issn1872-633Xen_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage117en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.indcrop.2015.11.088
dc.identifier.urihttps://hdl.handle.net/20.500.12395/33694
dc.identifier.volume81en_US
dc.identifier.wosWOS:000370088200014en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherELSEVIER SCIENCE BVen_US
dc.relation.ispartofINDUSTRIAL CROPS AND PRODUCTSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectImmunomodulatory activityen_US
dc.subjectEssential oilen_US
dc.subjectNatural compounden_US
dc.subjectTNF-alphaen_US
dc.subjectCytokineen_US
dc.subjectROSen_US
dc.subjectT-cell proliferationen_US
dc.titleImmunomodulatory properties of various natural compounds and essential oils through modulation of human cellular immune responseen_US
dc.typeArticleen_US

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