Impact of enriched environment on production of tau, amyloid precursor protein and, amyloid-beta peptide in high-fat and high-sucrose-fed rats

Basit Öğe Kaydı
dc.contributor.authorSelvi, Yavuz
dc.contributor.authorGergerlioğlu, Hasan Serdar
dc.contributor.authorAkbaba, Nursel
dc.contributor.authorÖz, Mehmet
dc.contributor.authorKandeğer, Ali
dc.contributor.authorDemir, Enver Ahmet
dc.contributor.authorYerlikaya, Fatma Hümeyra
dc.date.accessioned2020-03-26T19:41:51Z
dc.date.available2020-03-26T19:41:51Z
dc.date.issued2017
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective: The Western-type diet is associated with an elevated risk of Alzheimer's disease and other milder forms of cognitive impairment. The aim of the present study was to investigate the effects of the environmental enrichment on amyloid and tau pathology in high-fat and high-sucrose-fed rats. Methods: In total, 40 adult male rats were categorised into two main groups according to their housing conditions: enriched environment (EE, n = 16) and standard housing condition (n = 24). The groups were further divided into five subgroups that received standard diet, high-fat diet, and high-sucrose diet. We performed the analysis of amyloid beta-peptide (A beta) (1-40), A beta(1-42), amyloid precursor protein (APP), and tau levels in the hippocampus of rats that were maintained under standard housing conditions or exposed to an EE. Results: The EE decreased the A beta(1-40), A beta(1-42), APP, and tau levels in high-fat and high-sucrose-fed rats. Conclusion: This observation shows that EE may rescue diet-induced amyloid and tau pathology.en_US
dc.description.sponsorshipSelcuk University Scientific Research Projects Coordination UnitSelcuk University [15401033]en_US
dc.description.sponsorshipThe authors thank the Selcuk University Scientific Research Projects Coordination Unit for the financial support (Project No.: 15401033).en_US
dc.identifier.doi10.1017/neu.2016.63en_US
dc.identifier.endpage298en_US
dc.identifier.issn1601-5215en_US
dc.identifier.issue5en_US
dc.identifier.pmid27923413en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage291en_US
dc.identifier.urihttps://dx.doi.org/10.1017/neu.2016.63
dc.identifier.urihttps://hdl.handle.net/20.500.12395/35183
dc.identifier.volume29en_US
dc.identifier.wosWOS:000415942300004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherCAMBRIDGE UNIV PRESSen_US
dc.relation.ispartofACTA NEUROPSYCHIATRICAen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAlzheimer's diseaseen_US
dc.subjectamyloiden_US
dc.subjectdieten_US
dc.subjecthippocampusen_US
dc.subjecttauen_US
dc.titleImpact of enriched environment on production of tau, amyloid precursor protein and, amyloid-beta peptide in high-fat and high-sucrose-fed ratsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu