Effects of melatonin on the serum levels of pro-inflammatory cytokines and tissue injury after renal ischemia reperfusion in rats

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dc.contributor.authorOguz, Elif
dc.contributor.authorYilmaz, Zehra
dc.contributor.authorOzbilge, Hatice
dc.contributor.authorBaba, Fusun
dc.contributor.authorTabur, Suzan
dc.contributor.authorYerer, Mukerrem Betul
dc.contributor.authorHekimoglu, Askin
dc.date.accessioned2020-03-26T19:05:53Z
dc.date.available2020-03-26T19:05:53Z
dc.date.issued2015
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractWe investigated the changes in the serum levels of tumor necrosis factor (TNF)-alpha and interleukin (IL)-6, the pro-inflammatory cytokines, and the possible effect of melatonin on the modulation of these inflammatory molecules after renal ischemia reperfusion (IR). The study was carried out in the laboratory of Department of Pharmacology. Forty-six male Wistar albino rats were divided into five groups as control (n = 6), positive control (n = 4), sham (n = 12), renal IR (n = 12), and renal IR melatonin (n = 12). After 1 h renal pedicle occlusion, the blood samples were taken for the measurement of cytokine levels at second hour of the reperfusion. The rats were sacrificed after 24 h of reperfusion for histopathological evaluation. Melatonin or vehicle was administrated to IR rats. Lipopolysaccharide (LPS) was administered to the positive control group and the blood was taken at fourth hour. Serum TNF-alpha levels increased significantly in renal IR and LPS groups. Serum IL-6 levels were not different from control except the LPS group. There was no significant correlation between the serum TNF-alpha levels and the histopathological score after renal IR. Melatonin treatment reversed the increase of serum TNF-alpha levels and histopathological injury in renal tissue after renal IR. Melatonin may have a protective effect by reducing the serum level of TNF-alpha in renal IR.en_US
dc.identifier.doi10.3109/0886022X.2014.991263en_US
dc.identifier.endpage322en_US
dc.identifier.issn0886-022Xen_US
dc.identifier.issn1525-6049en_US
dc.identifier.issue2en_US
dc.identifier.pmid25519208en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage318en_US
dc.identifier.urihttps://dx.doi.org/10.3109/0886022X.2014.991263
dc.identifier.urihttps://hdl.handle.net/20.500.12395/32081
dc.identifier.volume37en_US
dc.identifier.wosWOS:000350554300007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTAYLOR & FRANCIS LTDen_US
dc.relation.ispartofRENAL FAILUREen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectCytokinesen_US
dc.subjectischemiaen_US
dc.subjectkidneyen_US
dc.subjectmelatoninen_US
dc.subjectreperfusionen_US
dc.titleEffects of melatonin on the serum levels of pro-inflammatory cytokines and tissue injury after renal ischemia reperfusion in ratsen_US
dc.typeArticleen_US

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