An investigation of non-depolarizing muscle relaxants on embryonic development in cultured rat embryos

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dc.contributor.authorKarabulut, AK
dc.contributor.authorReisli, R
dc.contributor.authorUysal, II
dc.contributor.authorCelik, JB
dc.contributor.authorZiylan, T
dc.date.accessioned2020-03-26T16:47:48Z
dc.date.available2020-03-26T16:47:48Z
dc.date.issued2004
dc.departmentSelçuk Üniversitesien_US
dc.description10th Annual Meeting of the European-Society-of-Anaesthesiologists -- APR 06-09, 2002 -- NICE, FRANCEen_US
dc.description.abstractBackground and objective: We have investigated the toxic and teratogenic effects of certain non-depolarizing muscle relaxants on embryonic development in cultured rat embryos. Methods: Rat embryos of 9.5 days were explanted and cultured in vitro for 48 h in rat serum. Whole rat serum was used as a culture medium for the control group while different concentrations of atracurium, cis-atracurium, rocuronium and mivacurium were added to rat serum for the experimental groups. Dose-dependent effects of these agents on embryonic developmental parameters were compared using morphological and biochemical methods. Each embryo was evaluated for the presence of any malformations. Results: When compared to the control embryos, the muscle relaxants significantly decreased all growth and developmental parameters dose dependently with an increase in overall dismorphology. Among these malformations, maxillary deformity was most frequently observed. These effects were observed in much lower doses with atracurium and cis-atracurium compared to those with rocuronium and mivacutium. Conclusions: Our results suggest that non-depolarizing muscle relaxants cause dose-dependent toxicity on rat embryos at concentrations much greater than those in clinical practice. Although, these agents seems to have a low potential for causing developmental toxicity during organogenesis, because of the lower toxic effects observed with rocuronium and mivacurium, these agents may be preferred when recurrent administrations are necessary for parturients.en_US
dc.description.sponsorshipEuropean Soc Anaesthesiologistsen_US
dc.identifier.doi10.1017/S0265021504009081en_US
dc.identifier.endpage724en_US
dc.identifier.issn0265-0215en_US
dc.identifier.issn1365-2346en_US
dc.identifier.issue9en_US
dc.identifier.pmid15595584en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage715en_US
dc.identifier.urihttps://dx.doi.org/10.1017/S0265021504009081
dc.identifier.urihttps://hdl.handle.net/20.500.12395/18937
dc.identifier.volume21en_US
dc.identifier.wosWOS:000225517500008en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLIPPINCOTT WILLIAMS & WILKINSen_US
dc.relation.ispartofEUROPEAN JOURNAL OF ANAESTHESIOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectneuromuscular non-depolarizing agents, atracurium, cis-atracurium, rocuronium, mivacuriumen_US
dc.subjectculture, whole embryo cultureen_US
dc.subjectpregnancy, toxicityen_US
dc.subjectratsen_US
dc.titleAn investigation of non-depolarizing muscle relaxants on embryonic development in cultured rat embryosen_US
dc.typeArticleen_US

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