Investigation of Oxidative Stress Markers in Essential Hypertension

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dc.contributor.authorToker, Aysun
dc.contributor.authorMehmetoglu, Idris
dc.contributor.authorYerlikaya, F. Humeyra
dc.contributor.authorNergiz, Suleyman
dc.contributor.authorKurban, Sevil
dc.contributor.authorGok, Hasan
dc.date.accessioned2020-03-26T18:42:15Z
dc.date.available2020-03-26T18:42:15Z
dc.date.issued2013
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground: The main goal of this study was to evaluate ischemia modified albumin (IMA), total antioxidant status (TAS), and total oxidant status (TOS) levels in treated essential hypertensive patients and to compare them with levels of normotensive subjects. Methods: In 45 hypertensive and 30 control subjects, serum levels of IMA were determined manually using a spectrophotometric Co(II)-albumin binding assay. TAS and TOS levels were evaluated spectrophotometrically. Lipid profile was estimated by routine methods. Results: Hypertensive patients had significantly higher levels of TOS and IMA (p = 0.020 and p = 0.034, respectively) and lower levels of TAS (p = 0.016) in comparison with control subjects. Serum levels of TAS were negatively correlated with TOS and IMA levels in the patient group. Serum levels of TOS were also positively correlated with IMA levels. There was no significant correlation between blood pressure and TAS, TOS, and IMA levels. Conclusions: Our results showed higher levels of IMA in hypertensive patients. We suggest that higher levels of IMA may result from increased oxidative stress and decreased antioxidant status in hypertensive patients.en_US
dc.identifier.doi10.7754/Clin.Lab.2012.120128en_US
dc.identifier.endpage114en_US
dc.identifier.issn1433-6510en_US
dc.identifier.issue01.02.2020en_US
dc.identifier.pmid23505914en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage107en_US
dc.identifier.urihttps://dx.doi.org/10.7754/Clin.Lab.2012.120128
dc.identifier.urihttps://hdl.handle.net/20.500.12395/29589
dc.identifier.volume59en_US
dc.identifier.wosWOS:000328912900013en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherCLIN LAB PUBLen_US
dc.relation.ispartofCLINICAL LABORATORYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectessential hypertensionen_US
dc.subjecttotal antioxidant statusen_US
dc.subjecttotal oxidant statusen_US
dc.subjectischemia modified albuminen_US
dc.titleInvestigation of Oxidative Stress Markers in Essential Hypertensionen_US
dc.typeArticleen_US

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