Platelet Distribution Width and Mean Platelet Volume in Children With Pulmonary Arterial Hypertension Secondary to Congenital Heart Disease With Left-to-Right Shunt: New Indices of Severity?

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dc.contributor.authorArslan, Derya
dc.contributor.authorCimen, Derya
dc.contributor.authorGuvenc, Osman
dc.contributor.authorKaya, Fatma
dc.contributor.authorSert, Ahmet
dc.contributor.authorOran, Bulent
dc.date.accessioned2020-03-26T18:42:54Z
dc.date.available2020-03-26T18:42:54Z
dc.date.issued2013
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe majority of patients with congenital heart disease (CHD), particularly those with relevant systemic-to-pulmonary shunts, if left untreated, will experience the development of pulmonary arterial hypertension (PAH). Previous studies have shown that platelet activation occurs in patients with PAH. In response, this study aimed to investigate the platelet indices, including platelet distribution width (PDW) and mean platelet volume (MPV), in patients with PAH. The study was conducted in the pediatrics cardiology unit of Selcuk University Medical Faculty between July 2010 and January 2012. The patients' clinical and laboratory data were obtained retrospectively from hospital recordings. The study enrolled 57 children with CHD (all with left-to-right shunting). The patients who had undergone diagnostic cardiac catheterization were analyzed according to the presence or absence of PAH. Group 1 had CHD with PAH, and group 2 had CHD without PAH. Compared with the group 2 patients, a significant decrease in PDW (p < 0.0001) was noted in the group 1 patients (with PAH). Likewise, a significant difference was found in the MPV of group 1 (p < 0.0001). Statistically, groups 1 and 2 did not differ in terms of platelet count (p = 0.3). Patients who had pulmonary hypertension secondary to CHD with left-to-right shunting exhibited a lower PDW and MPV.en_US
dc.identifier.doi10.1007/s00246-012-0600-5en_US
dc.identifier.endpage1016en_US
dc.identifier.issn0172-0643en_US
dc.identifier.issn1432-1971en_US
dc.identifier.issue4en_US
dc.identifier.pmid23254645en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1013en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s00246-012-0600-5
dc.identifier.urihttps://hdl.handle.net/20.500.12395/29731
dc.identifier.volume34en_US
dc.identifier.wosWOS:000316957900034en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSPRINGERen_US
dc.relation.ispartofPEDIATRIC CARDIOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectChildrenen_US
dc.subjectPlatelet distribution widthen_US
dc.subjectPrognosesen_US
dc.subjectPulmonary arterial hypertensionen_US
dc.titlePlatelet Distribution Width and Mean Platelet Volume in Children With Pulmonary Arterial Hypertension Secondary to Congenital Heart Disease With Left-to-Right Shunt: New Indices of Severity?en_US
dc.typeArticleen_US

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