Role of the Endothelium on the Response to Adrenoceptor Agonists of Rabbit Aorta During Cooling
Yükleniyor...
Dosyalar
Tarih
2000
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Editions Scientifiques Medicales Elsevier
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
The role of the endothelium in the effects of cooling on the response to alpha(1)- and alpha(2)-adrenoceptor agonists of rabbit aorta was studied. The contractions induced by clonidine (10(-9)-3 x 10(-4) M) and xylazine(10(-7)-10(-3) M) but not phenylephrine (10(-9)-3 x 10(-4) M) and methoxamine (10(-9)-3 x 10(-4) M) were enhanced in endothelium-denuded or N-G-nitro-L arginine methyl esther (L-NAME) (10(-5) M) pretreated rabbit aorta. The senstivity, but not the maximal response, of both alpha(1)- and alpha(2)-adrenoceptor agonists was significantly lower at 28 degrees C (cooling) than at 37 degrees C. Endothelium removal did not affect the action of cooling. These results were taken as evidence for the specificity of alpha(2)-adrenoceptor agonists on the production and release of nitric oxide from vascular endothelium. The results suggest that the endothelium seems to have no role in the cooling-induced responses of both alpha(1)- and alpha(2)-adrenoceptors. (C) 2000 Editions scientifiques et medicales Elsevier SAS.
Açıklama
Anahtar Kelimeler
aorta (rabbit), temperature, nitric oxide, alpha(1)-adrenoceptors, alpha(2)-adrenoceptors
Kaynak
Fundamental & Clinical Pharmacology
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
14
Sayı
1
Künye
Atalık, E. K., Şahin, A. S., Kılıç, M., Doğan, N., (2000). Role of the Endothelium on the Response to Adrenoceptor Agonists of Rabbit Aorta During Cooling. Fundamental & Clinical Pharmacology, 14(1), 25-30.
