The evaluation of carotid intima-media thickness in children with familial Mediterranean fever

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dc.contributor.authorPeru, Harun
dc.contributor.authorAltun, Bülent
dc.contributor.authorDoğan, Mustafa
dc.contributor.authorKara, Fatih
dc.contributor.authorElmacı, Ahmet Midhat
dc.contributor.authorOran, Bülent
dc.date.accessioned2020-03-26T17:28:08Z
dc.date.available2020-03-26T17:28:08Z
dc.date.issued2008
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe aim is to investigate whether pediatric familial Mediterranean fever (FMF) patients have an increased risk of premature atherosclerosis and to determine the possible strength of association between atherosclerosis and Mediterranean fever (MEFV) gene mutation gene type. Demographic characteristics and MEFV mutations were defined in 49 children diagnosed with FMF (26 female, 23 male; mean age, 10.71 +/- 3.69 years). Twenty-six age-, sex-, and body-mass-index-matched healthy children constituted the control group. We evaluated the blood counts and acute-phase proteins during attack-free periods. Mean C-reactive protein (CRP), serum amyloid-A (SAA), homocysteine (Hcy), lipoprotein-a (Lp-a), and common carotid artery intima-media thickness (CCA-IMT) were 10.75 +/- 15.29 vs 4.03 +/- 1.20, 23.22 +/- 1.94 vs 3.53 +/- 1.04, 10.36 +/- 3.36 vs 8.64 +/- 3.15, 20.84 +/- 23.89 vs 8.56 +/- 7.48, and 0.038 +/- 0.007 vs 0.032 +/- 0.004, respectively, and significantly higher than the mean values of control group (p < 0.05). However, no correlation was found between CCA-IMT and CRP, SAA, Hcy, and Lp-a. Twenty-nine patients had M694V mutation, and 13 patients had other mutations. There was no correlation between CCA-IMT and MEFV mutation subgroups. In conclusion, because of the nature of the disease, FMF patients should be considered to have an increased risk of early vascular alteration and atherosclerosis. For this reason, CCA-IMT measurement can be recommended as a noninvasive and early diagnostic method.en_US
dc.identifier.doi10.1007/s10067-007-0764-1en_US
dc.identifier.endpage694en_US
dc.identifier.issn0770-3198en_US
dc.identifier.issn1434-9949en_US
dc.identifier.issue6en_US
dc.identifier.pmid17926078en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage689en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s10067-007-0764-1
dc.identifier.urihttps://hdl.handle.net/20.500.12395/22722
dc.identifier.volume27en_US
dc.identifier.wosWOS:000255617500002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSPRINGER LONDON LTDen_US
dc.relation.ispartofCLINICAL RHEUMATOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAtherosclerosisen_US
dc.subjectCarotid intima-media thicknessen_US
dc.subjectFamilial Mediterranean feveren_US
dc.titleThe evaluation of carotid intima-media thickness in children with familial Mediterranean feveren_US
dc.typeArticleen_US

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