Effect of Weight Loss on Bone Metabolism: Comparison of Vertical Banded Gastroplasty and Medical Intervention

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dc.contributor.authorGüney, Engin
dc.contributor.authorKısakol, Gürcan
dc.contributor.authorÖzgen, Gökhan
dc.contributor.authorYılmaz, Candeğer
dc.contributor.authorYılmaz, Rasih
dc.contributor.authorKabalak, Taylan
dc.date.accessioned2020-03-26T16:45:38Z
dc.date.available2020-03-26T16:45:38Z
dc.date.issued2003
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground: We studied the effects of weight loss on bone metabolism. Methods: 16 consecutive surgically-treated (14 female, 2 male) morbidly obese patients and 65 obese (53 male, 12 female) medically-treated patients were enrolled in an observational study. Surgical treatment for morbidly obese patients was vertical banded gastroplasty (VBG). Studies were performed prior to and 12 months after the start of treatment. Bone mineral density (BMD), bone turnover markers, sex steroids, calcium excretion and parathyroid hormone measurements were done at each visit. Results: Weight loss was more prominent with surgical than with medical treatments. Bone loss was also pronounced in the surgical treatment group, and occurred at the hip level only (P<0.05). Compared to previously reported studies, where the effects of malabsorptive treatments for obesity on bone metabolism were studied, calcium excretion and parathyroid hormone levels did not change after VBG or medical therapy. For both groups, bone markers indicated an increased bone turnover, evidenced by increased urinary excretion of deoxypyridinoline and serum levels of osteocalcin (P<0.05). Sex steroid measurements revealed a decrease in estradiol levels in the surgical treatment group, but not in medical treatment group. This finding was thought to be secondary to less weight loss in the medical group. Conclusion: Our data indicate that weight loss causes bone loss. The bone loss is independent of the method of weight reduction. However, the mechanism of the bone loss is not clear. It may be explained partly by reduced estradiol levels in female patients. Because the mechanisms of bone disease after weight loss remain unclear, it is difficult to determine the most effective treatment. It is important to detect osteopenia early, before fractures occur. Measuring BMD appears to be the only reliable method for screening.en_US
dc.identifier.citationGüney, E., Kısakol, G., Özgen, G., Yılmaz, C., Yılmaz, R., Kabalak, T., (2003). Effect of Weight Loss on Bone Metabolism: Comparison of Vertical Banded Gastroplasty and Medical Intervention. Obesity Surgery, (13), 383-388. Doi: 10.1381/096089203765887705
dc.identifier.doi10.1381/096089203765887705en_US
dc.identifier.endpage388en_US
dc.identifier.issn0960-8923en_US
dc.identifier.issn1708-0428en_US
dc.identifier.pmid12841898en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage383en_US
dc.identifier.urihttps://dx.doi.org/10.1381/096089203765887705
dc.identifier.urihttps://hdl.handle.net/20.500.12395/18436
dc.identifier.volume13en_US
dc.identifier.wosWOS:000183512700012en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKısakol, Gürcan
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofObesity Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleEffect of Weight Loss on Bone Metabolism: Comparison of Vertical Banded Gastroplasty and Medical Interventionen_US
dc.typeArticleen_US

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