Henoch-Schonlein Nephritis: A Nationwide Study

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dc.contributor.authorSoylemezoglu, O.
dc.contributor.authorOzkaya, O.
dc.contributor.authorOzen, S.
dc.contributor.authorBakkaloglu, A.
dc.contributor.authorDusunsel, R.
dc.contributor.authorPeru, H.
dc.contributor.authorCetinyurek, A.
dc.date.accessioned2020-03-26T17:38:49Z
dc.date.available2020-03-26T17:38:49Z
dc.date.issued2009
dc.departmentSelçuk Üniversitesien_US
dc.description39th Annual Meeting of the European-Society-for-Paediatric-Nephrology -- SEP 10-13, 2005 -- Istanbul, TURKEYen_US
dc.description.abstractBackground/Aim: The aim of this retrospective study was to evaluate the presentation, clinical and pathological manifestations and outcome of the Henoch-Schonlein purpura (HSP) nephritis in children. Methods: Clinical and laboratory data of 443 children with HSP nephritis aged between 3 and 16 years from 16 pediatric nephrology reference centers were analyzed retrospectively. The biopsy findings were graded according to the classification developed by the International Study of Kidney Disease in Children (ISKDC). Results: Renal biopsy was performed in 179 of the patients with HSP nephritis. The most common presenting clinical finding in patients who were biopsied was nephrotic range proteinuria (25%) which was followed by nephritic-nephrotic syndrome (23.5%). The biopsy findings according to the ISKDC were as follows: class I: 8.3%; II: 44.1%; III: 36.3%; IV: 6.7%; V: 3.3%; VI: 1.1%. All of the patients who developed end-stage renal disease had nephritic-nephrotic syndrome at presentation. Of 443 patients, 87.2% had a favorable outcome and 12.8% had an unfavorable outcome. The overall percentage of children who developed end-stage renal disease at follow-up was 1.1%. Logistic regression analysis did not show any association of initial symptoms and histology with outcome. Conclusion: In the presented cohort, the presence of crescents in the first biopsy or presenting clinical findings did not seem to predict the outcome of HSP nephritis in children. We conclude that children with HSP nephritis even with isolated microscopic hematuria and/or mild proteinuria should be followed closely. Copyright (C) 2009 S. Karger AG, Baselen_US
dc.description.sponsorshipEuropean Soc Paediat Nephrolen_US
dc.identifier.doi10.1159/000218109en_US
dc.identifier.endpageC204en_US
dc.identifier.issn1660-2110en_US
dc.identifier.issue3en_US
dc.identifier.pmid19439991en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpageC199en_US
dc.identifier.urihttps://dx.doi.org/10.1159/000218109
dc.identifier.urihttps://hdl.handle.net/20.500.12395/23582
dc.identifier.volume112en_US
dc.identifier.wosWOS:000266882400012en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKARGERen_US
dc.relation.ispartofNEPHRON CLINICAL PRACTICEen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectChildrenen_US
dc.subjectHenoch-Schonlein purpuraen_US
dc.subjectNephritisen_US
dc.subjectOutcomeen_US
dc.subjectTreatmenten_US
dc.titleHenoch-Schonlein Nephritis: A Nationwide Studyen_US
dc.typeArticleen_US

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