Phenotyping of chronic obstructive pulmonary disease using the modified Bhalla scoring system for high-resolution computed tomography

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dc.contributor.authorTulek, Baykal
dc.contributor.authorKivrak, Ali Sami
dc.contributor.authorOzbek, Seda
dc.contributor.authorKanat, Fikret
dc.contributor.authorSuerdem, Mecit
dc.date.accessioned2020-03-26T18:42:52Z
dc.date.available2020-03-26T18:42:52Z
dc.date.issued2013
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBACKGROUND: Identifying different phenotypes of chronic obstructive pulmonary disease (COPD) is important for both therapeutic options and clinical outcome of the disease. OBJECTIVE: To characterize the phenotypes of COPD according to high-resolution computed tomography (HRCT) findings; and to correlate HRCT scores obtained using the modified Bhalla scoring system with clinical and physiological indicators of systemic inflammation. METHODS: The present study included 80 consecutive patients with stable COPD. HRCT scans were evaluated by two independent radiologists according to the modified Bhalla scoring system. RESULTS: Fifty-four patients exhibited morphological changes on HRCT examination while 26 had no pathological findings. Patients with HRCT findings had lower spirometric measurements and higher levels of inflammation, and reported more exacerbations in the previous year compared with patients with no findings on HRCT. Patients with morphological changes were classified into one of three groups according to their HRCT phenotype(s): emphysema (E) only, E + bronchiectasis (B)/peribronchial thickening (PBT) or B/PBT only. Forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), FEV1/FVC ratio, C-reactive protein (CRP) levels and the number of exacerbations among the groups were significantly different. Pairwise comparisons between the E only and E+B/PBT groups showed significantly lower FVC, FEV1 and FEV1/FVC values, and higher CRP levels and number of exacerbations compared with the B/PBT group. No significant differences were found between the E+B/PBT and the B/PBT groups. An inverse correlation was found between the total HRCT score and FVC, FEV1 and FEV1/FVC; the correlation was positive with CRP level, erythrocyte sedimentation rate and number of exacerbations. CONCLUSION: The present study exposed the intimate relationship between phenotype(s) characterized by HRCT and scoring for morphological abnormalities; and clinical and functional parameters and inflammatory markers. The inclusion of HRCT among routine examinations for COPD may provide significant benefits both in the management and prognosis of COPD patients.en_US
dc.identifier.doi10.1155/2013/727523en_US
dc.identifier.endpage96en_US
dc.identifier.issn1198-2241en_US
dc.identifier.issn1916-7245en_US
dc.identifier.issue2en_US
dc.identifier.pmid23616965en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage91en_US
dc.identifier.urihttps://dx.doi.org/10.1155/2013/727523
dc.identifier.urihttps://hdl.handle.net/20.500.12395/29725
dc.identifier.volume20en_US
dc.identifier.wosWOS:000323576200009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherHINDAWI LTDen_US
dc.relation.ispartofCANADIAN RESPIRATORY JOURNALen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectChronic obstructive pulmonary diseaseen_US
dc.subjectHigh-resolution computed tomographyen_US
dc.subjectPhenotypeen_US
dc.titlePhenotyping of chronic obstructive pulmonary disease using the modified Bhalla scoring system for high-resolution computed tomographyen_US
dc.typeArticleen_US

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