Soluble platelet glycoprotein V in distinct disease states of pathological thrombopoiesis

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dc.contributor.authorAcar, Kadir
dc.contributor.authorAksu, Salih
dc.contributor.authorBeyazit, Yavuz
dc.contributor.authorHaznedaroglu, Ibrahim C.
dc.contributor.authorKoca, Ebru
dc.contributor.authorCetiner, Deniz
dc.contributor.authorSayinalp, Nilguen
dc.date.accessioned2020-03-26T17:27:47Z
dc.date.available2020-03-26T17:27:47Z
dc.date.issued2008
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractQuantitative platelet disorders (i.e., thrombocytosis or thrombocytopenia) may also be associated with qualitative platelet alterations. Clonal thrombocythemia (CT), reactive thrombocytosis (RT), immune thrombocytopenic purpura (ITP), and thrombocytopenia of aplastic pancytopenia (AA) or infiltrative bone marrow disorders represent the major classes of pathological thrombopoiesis. Glycoprotein V may serve as an in vivo marker of platelet activation in thrombotic and hemorrhagic states. The aim of this study was to assess circulating plasma soluble platelet glycoprotein V (sGPV) concentrations in distinct disease states of pathological thrombopoiesis. The whole study group comprised 20 patients with thrombocytopenia, 32 patients with thrombocytosis and 14 healthy adults as the control group. sGPV was significantly increased in the group of thrombocytosis patients in comparison to the thrombocytopenic group and the healthy control groups. When sGPV levels were corrected according to platelet number (sGPV/tr), this ratio was very high in patients with thrombocytopenia compared to patients with thrombocytosis and the control group. Our results suggest that there is an ongoing platelet activation associated with thrombocytosis regardless of its origin is either CT or RT. Therefore, glycoprotein V system may serve to activate residual platelets in thrombocytopenia regardless of its origin is either ITP or AA.en_US
dc.identifier.doi10.1016/S0027-9684(15)31180-9en_US
dc.identifier.endpage90en_US
dc.identifier.issn0027-9684en_US
dc.identifier.issn1943-4693en_US
dc.identifier.issue1en_US
dc.identifier.pmid18277814en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage86en_US
dc.identifier.urihttps://dx.doi.org/10.1016/S0027-9684(15)31180-9
dc.identifier.urihttps://hdl.handle.net/20.500.12395/22646
dc.identifier.volume100en_US
dc.identifier.wosWOS:000252625300013en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherNATL MED ASSOCen_US
dc.relation.ispartofJOURNAL OF THE NATIONAL MEDICAL ASSOCIATIONen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectplateletsen_US
dc.subjectthrombocytopeniaen_US
dc.titleSoluble platelet glycoprotein V in distinct disease states of pathological thrombopoiesisen_US
dc.typeArticleen_US

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