The effect of allergen immunotherapy on serum periostin levels in children with allergic rhinitis

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dc.authorid0000-0002-0287-5260
dc.authorid0000-0003-3028-3112
dc.authorid0000-0002-3484-6026
dc.authorid0000-0002-0204-6657
dc.authorid0000-0002-9991-3939
dc.authorid0000-0002-9807-2605
dc.contributor.authorUcaryilmaz, Hulya
dc.contributor.authorEmsen, Ayca
dc.contributor.authorDikener, Ahmet Hakan
dc.contributor.authorAkdam, Neriman
dc.contributor.authorUnlu, Ali
dc.contributor.authorArtac, Hasibe
dc.date.accessioned2020-03-26T20:19:23Z
dc.date.available2020-03-26T20:19:23Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Tıp Fakültesi, Tıbbi Biyokimya Bölümüen_US
dc.description.abstractObjective: Periostin, an extracellular matrix protein, is related to the eosinophilic airway inflammation. There is no specific marker in allergen immunotherapy to evaluate clinical response. We aimed to investigate the serum periostin levels in the children who receive allergen immunotherapy. Materials and Methods: Sixteen patients between 8-18 years (12.7 +/- 2.8 years) with allergic rhinitis and/or asthma due to grass pollen hypersensitivity and 30 healthy subjects (11.7 +/- 2.6 years) were included. Demographic data, eosinophil counts, skin prick tests and the specific IgE levels of the patients are recorded. Symptom scores, visual analog scales, medication scores were determined and the serum periostin levels were measured in the beginning, 4th and 12th months of the allergen immunotherapy. Results: The symptom scores for rhinitis in the 4th month showed significant improvements in all of the patients (p< 0.05). Nine patients with allergic rhinitis accompanied by asthma, showed significant improvements in 12th month symptom score for asthma (p=0.018). A significant correlation was detected between the initial serum periostin levels and the symptom scores for the eye (r=0.668, p=0.005). No significant difference was found in serum periostin levels between the patient and the control groups. There were no significant differences in serum periostin levels in 4th and 12th months compared to the ones in the beginning. Conclusion: In this study, there were no significant differences in serum periostin levels of children during the allergen immunotherapy. The association of serum periostin levels with symptom scores for the eye needs to be confirmed in more children with allergic rhinoconjunctivitis.en_US
dc.identifier.citationUcaryilmaz, H., Emsen, A., Dikener, A. H., Akdam, N., Unlu, A., Artac, H. (2019). The Effect of Allergen Immunotherapy on Serum Periostin Levels in Children with Allergic Rhinitis. Astım Allerji Immunoloji, 17(2), 83-90.
dc.identifier.doi10.21911/aai.435en_US
dc.identifier.endpage90en_US
dc.identifier.issn1308-9234en_US
dc.identifier.issue2en_US
dc.identifier.pmid#YOKen_US
dc.identifier.startpage83en_US
dc.identifier.urihttps://dx.doi.org/10.21911/aai.435
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38246
dc.identifier.volume17en_US
dc.identifier.wosWOS:000480413700005en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.institutionauthorUcaryilmaz, Hulya
dc.institutionauthorAkdam, Neriman
dc.institutionauthorArtac, Hasibe
dc.language.isoenen_US
dc.publisherBILIMSEL TIP YAYINEVIen_US
dc.relation.ispartofASTIM ALLERJI IMMUNOLOJIen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAllergen immunotherapyen_US
dc.subjectallergic rhinitisen_US
dc.subjectasthmaen_US
dc.subjectserum periostinen_US
dc.titleThe effect of allergen immunotherapy on serum periostin levels in children with allergic rhinitisen_US
dc.typeArticleen_US

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