The relationship between uric acid and erectile dysfunction in hypertensive subjects

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dc.contributor.authorAribas, Alpay
dc.contributor.authorKayrak, Mehmet
dc.contributor.authorUlucan, Seref
dc.contributor.authorKeser, Ahmet
dc.contributor.authorDemir, Kenan
dc.contributor.authorAlibasic, Hayrudin
dc.contributor.authorAkilli, Hakan
dc.date.accessioned2020-03-26T18:58:40Z
dc.date.available2020-03-26T18:58:40Z
dc.date.issued2014
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground. Endothelial dysfunction plays a major role in erectile dysfunction (ED). Uric acid (UA) is a marker of endothelial dysfunction. We hypothesized that increased UA levels may be associated with ED and aimed to investigate whether there is a relationship between, UA and ED in hypertensive patients. Methods. A total of 200 hypertensive patients who have a normal treadmill exercise test were divided into two groups based on the Sexual Health Inventory for Men (SHIM) test (<21 defi ned as ED n = 110, and >= 21 defi ned as normal erectile function n = 90). The differences between the ED and normal erectile function groups were compared and determinants of ED were analyzed. Main results. The prevalence of ED was found to be 55.0%. Office blood pressure level was comparable between groups. UA levels were significantly increased in the ED group (6.20 +/- 1.56 vs 5.44 +/- 1.32, p = 0.01). In a regression model, age [odds ratio (95% confidence interval): 1.08 (1.04-1.14), p = 0.001], smoking [odds ratio: 2.33 (1.04-5.20), p = 0.04] and UA [odds ratio: 1.76 (1.28-2.41), p = 0.04] were independent determinants of ED. An UA level of >5.2 mg/dl had 76.2% sensitivity, 43.7% specificity, 62.9% positive and 59.4% negative predictive value for determining ED. Conclusion. UA is an independent determinant of ED irrespective of blood pressure control and questioning erectile function for hypertensive patients with increased UA levels may be recommended.en_US
dc.identifier.doi10.3109/08037051.2014.933032en_US
dc.identifier.endpage376en_US
dc.identifier.issn1651-1999en_US
dc.identifier.issue6en_US
dc.identifier.pmid25029530en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage370en_US
dc.identifier.urihttps://dx.doi.org/10.3109/08037051.2014.933032
dc.identifier.urihttps://hdl.handle.net/20.500.12395/31231
dc.identifier.volume23en_US
dc.identifier.wosWOS:000344768000008en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTAYLOR & FRANCIS LTDen_US
dc.relation.ispartofBLOOD PRESSUREen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectEndothelial dysfunctionen_US
dc.subjecterectile dysfunctionen_US
dc.subjecthypertensionen_US
dc.subjecturic aciden_US
dc.titleThe relationship between uric acid and erectile dysfunction in hypertensive subjectsen_US
dc.typeArticleen_US

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