Paediatric myelodysplastic syndrome (MDS) and juvenile chronic myelogenous leukaemia (JCML) detected by cytogenetic and FISH techniques

Basit Öğe Kaydı
dc.contributor.authorAcar, Hasan
dc.contributor.authorÇalışkan, O.
dc.contributor.authorÇora, Tülin
dc.date.accessioned2020-03-26T16:27:14Z
dc.date.available2020-03-26T16:27:14Z
dc.date.issued1999
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThis report presents two rare cases, one of paediatric myelodysplastic syndrome (MDS) and the other juvenile chronic myeloid leukaemia (jCML). In the first case, there were clinical and biological features of MDS-refractory anaemia with excess blasts (RAEB). The bone marrow (BM) karyotype demonstrated a monosomy 7 which was confirmed by fluorescence in situ hybridization (FISH). In addition, FISH analysis showed that an alpha-satellite DNA sequence had been transferred from chromosomes 13/21 to one homologue of chromosomes 22. The BCR-ABL rearrangement was negative. In the second case, at diagnosis, the karyotype was 46,XX. FISH analysis with the simultaneous and individual application of abl and bcr probes for chromosome 9 and 22, respectively, revealed the presence of the BCR-ABL rearrangement in addition to an extra ABL sequence locating chromosome 20. A clone that was BCR-ABL gene rearrangement negative but with an extra ABL DNA sequence on chromsome 20, and another clone that was BCR-ABL gene rearrangement negative were detected by DC-FISH and uni-colour (UC-) FISH analysis. No monosomy 7 was detected by conventional cytogenetic or FISH analyses.en_US
dc.identifier.endpage406en_US
dc.identifier.issn0141-9854en_US
dc.identifier.issue6en_US
dc.identifier.pmid10671994en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage403en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/16964
dc.identifier.volume21en_US
dc.identifier.wosWOS:000085501100007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWILEYen_US
dc.relation.ispartofCLINICAL AND LABORATORY HAEMATOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectBCR-ABL rearrangementen_US
dc.subjectJCMLen_US
dc.subjectMDS-RAEBen_US
dc.subjectmonosomy 7en_US
dc.subjectPh chromosome negativeen_US
dc.titlePaediatric myelodysplastic syndrome (MDS) and juvenile chronic myelogenous leukaemia (JCML) detected by cytogenetic and FISH techniquesen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu