N-Acetylcysteine Prevents Vasospasm After Subarachnoid Hemorrhage

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dc.contributor.authorGüney, Önder
dc.contributor.authorErdi, Fatih
dc.contributor.authorEsen, Hasan
dc.contributor.authorKıyıcı, Aysel
dc.contributor.authorKocaoğullar, Yalçın
dc.date.accessioned2020-03-26T18:04:43Z
dc.date.available2020-03-26T18:04:43Z
dc.date.issued2010
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground: This study investigated the ability of NAC to prevent cerebral vasospasm in a rabbit model of SAH. Methods: Twenty-one, male New Zealand white rabbits were randomly divided into 3 groups of 7 rabbits each: group 1 (control), group 2 (SAH only), group 3 (SAH + NAC treatment). NAC (150 mg/kg, single dose, IF) was administered just before SAH and continued until 72 hours after SAH in group 3. Animals were killed 72 hours after SAH. Tissue MDA levels, SOD, and GSH-Px activities were measured, and basilar artery cross-sectional areas, arterial wall thickness, and endothelial apoptosis in a cross section of basillary artery were determined in all groups. Results: Intraperitoneal administration of NAC was found to be. markedly effective against developing a cerebral vasospasm following a SAH in rabbits. It could significantly reduce elevated lipid peroxidation and increase the level of tissue GSH-Px and SOD enzymatic activities. Also, NAC treatment was found to be effective in increasing the luminal area and reducing wall thickness of the basilar artery. The morphology of arteries in the NAC treatment group was well protected. NAC markedly reduced apoptotic index and protects the endothelial integrity. Conclusions: This study demonstrates, for the first time, that NAC treatment attenuates cerebral vasospasm in a rabbit SAH model. NAC treatment has significant neuroprotective effect and markedly prevents cerebral vasospasm after SAH. In conclusion, the NAC treatment might be beneficial in preventing cerebral vasospasm after SAH, thus showing potential for clinical implications.en_US
dc.identifier.citationGüney, Ö., Erdi, F., Esen, H., Kıyıcı, A., Kocaoğullar, Y., (2010). N-Acetylcysteine Prevents Vasospasm After Subarachnoid Hemorrhage. World Neurosurgery, 73(1), 42-49. DOI: 10.1016/j.surneu.2009.06.003
dc.identifier.doi10.1016/j.surneu.2009.06.003en_US
dc.identifier.endpage49en_US
dc.identifier.issn1878-8750en_US
dc.identifier.issue1en_US
dc.identifier.pmid20452867en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage42en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.surneu.2009.06.003
dc.identifier.urihttps://hdl.handle.net/20.500.12395/25095
dc.identifier.volume73en_US
dc.identifier.wosWOS:000292625900006en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorGüney, Önder
dc.institutionauthorErdi, Fatih
dc.institutionauthorEsen, Hasan
dc.institutionauthorKıyıcı, Aysel
dc.institutionauthorKocaoğullar, Yalçın
dc.language.isoenen_US
dc.publisherELSEVIER SCIENCE INCen_US
dc.relation.ispartofWorld Neurosurgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectN-Acetylcysteineen_US
dc.subjectSubarachnoid Hemorrhageen_US
dc.subjectVasospasmen_US
dc.subjectRabbiten_US
dc.titleN-Acetylcysteine Prevents Vasospasm After Subarachnoid Hemorrhageen_US
dc.typeArticleen_US

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