Are serum levels of ADAMTS5, TAS and TOS at 24–28 gestational weeks associated with adverse perinatal outcomes in gestational diabetic women?

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dc.authorid0000-0002-2996-3236
dc.authorid0000-0002-9366-867X
dc.contributor.authorOzler, Sibel.
dc.contributor.authorOztas, Efser.
dc.contributor.authorGuler, Basak Gumus.
dc.contributor.authorErel, Ozcan.
dc.contributor.authorCaglar, Ali Turhan.
dc.contributor.authorErgin, Merve.
dc.contributor.authorUygur, Dilek.
dc.date.accessioned2020-03-26T20:12:35Z
dc.date.available2020-03-26T20:12:35Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractWe aimed to determine the role of placental A Disintegrin and Metalloproteinase with thrombospondin motifs 5 (ADAMTS5), and maternal serum ADAMTS5, total antioxidant status (TAS), total oxidant status (TOS) and oxidative stress index (OSI) levels at 24-28th gestational weeks in GDM. This study included 57 patients, who had been diagnosed as having GDM at their 24-28th gestational week, and 29 controls. The maternal blood samples were collected at the 24-28th gestational week and ADAMTS5 was studied with the enzyme-linked immunosorbent assay (ELISA) method, whereas an automated colorimetric method was used to study TAS, TOS, and OSI. The level of ADAMTS5 in maternal serum of patients with GDM were significantly lower than the controls (p = .017); whereas TOS and OSI levels were significantly higher (p = .003 and p = .008). Multivariable logistic regression analysis revealed ADAMTS5 and TOS levels were independently associated with adverse perinatal outcomes (p = .004 and p = .018). We found that serum ADAMTS5 levels decreased and TOS level increased in GDM pregnant at 24-28th gestational weeks. In addition, we found that increased levels of serum ADAMTS5 and decreased TOS levels at 24-28th weeks were associated with adverse perinatal outcomes independent of the mode of treatment in GDM.Impact statement What is already known on this subject? Gestational diabetes mellitus (GDM) is one of the most common medical complications of pregnancy. The insulin resistance, which starts at the 24-28th gestational weeks, increases during gestation. GDM increases maternal complications like preeclampsia, cesarean rate, cardiovascular disease, obesity, and diabetes after pregnancy; and neonatal complications like macrosomia, hypoglycemia, hyperbilirubinemia, delivery trauma, shoulder dystocia, and adult-onset obesity, and diabetes. What the results of this study add? A significant relationship between ADAMTS5, TOS levels and adverse perinatal outcome. insulin resistance and was observed.en_US
dc.identifier.citationOzler, S., Oztas, E., Guler, B. G., Erel, O., Cağlar, A. T., Ergin, M., Uygur, D., Danisman, N. (2019). Are Serum Levels of ADAMTS5, TAS and TOS at 24-28 Gestational Weeks Associated with Adverse Perinatal Outcomes in Gestational Diabetic Women?. Journal of Obstetrics and Gynaecology, 40(5), 619-625.
dc.identifier.doi10.1080/01443615.2019.1634025en_US
dc.identifier.endpage625
dc.identifier.issn0144-3615en_US
dc.identifier.issn1364-6893en_US
dc.identifier.issue5
dc.identifier.pmid31526197en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage619
dc.identifier.urihttps://dx.doi.org/10.1080/01443615.2019.1634025
dc.identifier.urihttps://hdl.handle.net/20.500.12395/37494
dc.identifier.volume40
dc.identifier.wosWOS:000486770000001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorOzler, Sibel.
dc.language.isoenen_US
dc.publisherTAYLOR & FRANCIS INCen_US
dc.relation.ispartofJOURNAL OF OBSTETRICS AND GYNAECOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectA disintegrin and metalloproteinase with thrombospondin motifs 5en_US
dc.subjecttotal antioxidant statusen_US
dc.subjecttotal oxidant statusen_US
dc.subjectoxidative stress indexen_US
dc.subjectgestational diabetesen_US
dc.titleAre serum levels of ADAMTS5, TAS and TOS at 24–28 gestational weeks associated with adverse perinatal outcomes in gestational diabetic women?en_US
dc.typeArticleen_US

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