Improvement of catalytic activity of Candida rugosa lipase in the presence of calix[4]arene bearing iminodicarboxylic/phosphonic acid complexes modified iron oxide nanoparticles

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dc.contributor.authorÖzyılmaz, Elif
dc.contributor.authorBayrakçı, Mevlüt
dc.contributor.authorYılmaz, Mustafa
dc.date.accessioned2020-03-26T19:24:39Z
dc.date.available2020-03-26T19:24:39Z
dc.date.issued2016
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractIn the present study, iron oxide magnetite nanoparticles, prepared through a co-precipitation method, were coated with phosphonic acid or iminodicarboxylic acid derivatives of calix[4]arene to modulate their surfaces with different acidic groups. Candida rugosa lipase was then directly immobilized onto the modified nanoparticles through sol-gel encapsulation. The catalytic activities and enantioselectivities of the two encapsulated lipases in the hydrolysis reaction of (R/S)-naproxen methyl ester and (R/S)-2-phenoxypropionic acid methyl ester were assessed. The results showed that the activity and enantioselectivity of the lipase were improved when the lipase was encapsulated in the presence of calixarene-based additives; the encapsulated lipase with the phosphonic acid derivative of calix[4]arene had an excellent rate of enantioselectivity against the (R/S)-naproxen methyl and (R/S)-2-phenoxypropionic acid methyl esters, with E = 350 and 246, respectively, compared to the free enzyme. The encapsulated lipases (Fe-Calix-N(COOH)) and (Fe-Calix-P) showed good loading ability and little loss of enzyme activity, and the stability of the catalyst was very good; they only lost 6-11% of the enzyme's activity after five batches. (C) 2015 Elsevier Inc. All rights reserved.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK grant)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [111T027]; Research Foundation of Selcuk University (BAP)Selcuk Universityen_US
dc.description.sponsorshipThe financial support the Scientific and Technological Research Council of Turkey (TUBITAK grant no: 111T027), and the Research Foundation of Selcuk University (BAP) is gratefully acknowledged.en_US
dc.identifier.doi10.1016/j.bioorg.2015.12.001en_US
dc.identifier.endpage8en_US
dc.identifier.issn0045-2068en_US
dc.identifier.issn1090-2120en_US
dc.identifier.pmid26698535en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.bioorg.2015.12.001
dc.identifier.urihttps://hdl.handle.net/20.500.12395/33700
dc.identifier.volume65en_US
dc.identifier.wosWOS:000372324400001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherACADEMIC PRESS INC ELSEVIER SCIENCEen_US
dc.relation.ispartofBIOORGANIC CHEMISTRYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectCalix[4]areneen_US
dc.subjectMagnetite nanoparticlesen_US
dc.subjectEnantioselectiveen_US
dc.subjectLipase immobilizationen_US
dc.titleImprovement of catalytic activity of Candida rugosa lipase in the presence of calix[4]arene bearing iminodicarboxylic/phosphonic acid complexes modified iron oxide nanoparticlesen_US
dc.typeArticleen_US

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